Ecsedy Mónika, Súndor Gúbor L, Takúcs Úgnes I, Krúnitz Kinga, Kiss Zoltún, Kolev Krasimir, Nagy Zoltún Z
Department of Ophthalmology, Semmelweis University, Budapest - Hungary.
Department of Polymer Engineering, Faculty of Mechanical Engineering, University of Technology and Economics, Budapest - Hungary.
Eur J Ophthalmol. 2015 Nov-Dec;25(6):507-11. doi: 10.5301/ejo.5000603. Epub 2015 Apr 9.
To report the surgical treatment of 3 eyes of 2 patients with bilateral anterior lenticonus due to Alport syndrome using femtosecond laser-assisted cataract surgery (FLACS).
Two patients with Alport syndrome presented to our department due to anterior lenticonus in both eyes. We performed FLACS with posterior chamber lens implantation in both eyes of one patient and in one eye of the other patient. Anterior segment morphologic changes were visualized with a Scheimpflug camera, and anterior segment optical coherence tomography preoperatively and 3 months after surgery. Ultrastructure of the cut capsule edges was observed with scanning electron microscopy and compared to the edge of femtosecond laser capsulotomy performed on an otherwise healthy patient with cataract (control).
The intraocular lens (IOL) postoperative positioning parameters met the international requirements of aspherical and wavefront customized IOLs (tilt <10 degree, decentration <800 µm). Scanning electron microscopy revealed the same characteristics of the cut capsule edges in the Alport and in the control eyes.
Femtosecond laser cataract surgery can be a safe and successful method for optical rehabilitation of anterior lenticonus in patients with Alport syndrome.
报告使用飞秒激光辅助白内障手术（FLACS）治疗2例Alport综合征所致双眼前圆锥形晶状体患者的3只眼的手术情况。
2例Alport综合征患者因双眼前圆锥形晶状体前来我院就诊。我们对其中1例患者的双眼以及另1例患者的单眼进行了FLACS联合后房型人工晶状体植入术。使用眼前节照相机观察眼前节形态学变化，并在术前及术后3个月进行眼前节光学相干断层扫描。用扫描电子显微镜观察切开的晶状体囊膜边缘的超微结构，并与在1例患有白内障的健康患者（对照）身上进行的飞秒激光晶状体囊切开术的边缘进行比较。
人工晶状体（IOL）术后定位参数符合非球面和波前定制IOL的国际要求（倾斜度<10度，偏心度<800 µm）。扫描电子显微镜显示Alport综合征患者和对照眼中切开的晶状体囊膜边缘具有相同的特征。
飞秒激光白内障手术对于Alport综合征患者前圆锥形晶状体的光学康复可能是一种安全且成功的方法。
