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Rheumatoid arthritis: IL-6 inhibition in RA--déjà vu all over again?

作者信息

Ruderman Eric M

机构信息

Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, 675 North St Clair, Suite 14-100, Chicago, IL 60611, USA.

出版信息

Nat Rev Rheumatol. 2015 Jun;11(6):321-2. doi: 10.1038/nrrheum.2015.58. Epub 2015 Apr 28.

DOI:10.1038/nrrheum.2015.58
PMID:25907702
Abstract
摘要

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Arthritis Rheumatol. 2015 Jun;67(6):1424-37. doi: 10.1002/art.39093.
2
Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy.司鲁单抗,一种人源抗白细胞介素-6 单克隆抗体:在甲氨蝶呤治疗仍有活性的类风湿关节炎患者中进行的一项随机、两部分(概念验证和剂量发现)、II 期研究。
Ann Rheum Dis. 2014 Sep;73(9):1616-25. doi: 10.1136/annrheumdis-2013-205137. Epub 2014 Apr 3.
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短期、低剂量白细胞介素 2 联合托珠单抗治疗类风湿关节炎的疗效和安全性。
Front Immunol. 2024 Apr 22;15:1359041. doi: 10.3389/fimmu.2024.1359041. eCollection 2024.
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Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.巴维亭通过 PPARG/PI3K/AKT 信号通路改善类风湿性关节炎炎症。
Inflammation. 2023 Oct;46(5):1981-1996. doi: 10.1007/s10753-023-01855-w. Epub 2023 Jun 26.
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Pharmacokinetics and Pharmacodynamics of Subcutaneous Sarilumab and Intravenous Tocilizumab Following Single-Dose Administration in Patients With Active Rheumatoid Arthritis on Stable Methotrexate.皮下注射沙利鲁单抗和静脉注射托珠单抗在稳定接受甲氨蝶呤治疗的活动期类风湿关节炎患者单次给药后的药代动力学和药效学
J Clin Pharmacol. 2021 Jan;61(1):90-104. doi: 10.1002/jcph.1703. Epub 2020 Jul 29.
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Population Pharmacokinetic-Pharmacodynamic Relationships of Sarilumab Using Disease Activity Score 28-Joint C-Reactive Protein and Absolute Neutrophil Counts in Patients with Rheumatoid Arthritis.类风湿关节炎患者的 Sarilumab 基于疾病活动评分 28 关节 C 反应蛋白和绝对中性粒细胞计数的群体药代动力学-药效学关系。
Clin Pharmacokinet. 2020 Nov;59(11):1451-1466. doi: 10.1007/s40262-020-00899-7.
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