Awan Musaddiq, Liu Stanley, Sahgal Arjun, Das Sunit, Chao Samuel T, Chang Eric L, Knisely Jonathan P S, Redmond Kristin, Sohn Jason W, Machtay Mitchell, Sloan Andrew E, Mansur David B, Rogers Lisa R, Lo Simon S
Department of Radiation Oncology, Case Western Reserve University, University Hospitals Seidman Cancer Center, Cleveland, OH, USA.
Expert Rev Anticancer Ther. 2015 May;15(5):545-52. doi: 10.1586/14737140.2015.1028374.
Extra-CNS metastasis from glioblastoma (ECMGBM) is an emerging but little known clinical entity. We review pre-clinical and translational publications assessing the ability of GBM to spread locally and outside the CNS. Reported cases demonstrating ECMGBM are reviewed providing a summary of presentations for the entity. Special attention is placed on transmission of GBM through organ transplantation. Finally, predictions are made as to the future significance of ECMGBM, especially in the context of better outcomes in CNS GBM.
胶质母细胞瘤的中枢神经系统外转移（ECMGBM）是一种新出现但鲜为人知的临床实体。我们回顾了评估胶质母细胞瘤在中枢神经系统内局部扩散及向中枢神经系统外扩散能力的临床前和转化医学出版物。对已报道的显示ECMGBM的病例进行了回顾，总结了该实体的临床表现。特别关注了胶质母细胞瘤通过器官移植的传播情况。最后，对ECMGBM未来的意义进行了预测，尤其是在中枢神经系统胶质母细胞瘤预后改善的背景下。
