McDiarmid Melissa A, Gaitens Joanna M, Hines Stella, Condon Marian, Roth Tracy, Oliver Marc, Gucer Patricia, Brown Lawrence, Centeno Jose A, Streeten Elizabeth, Squibb Katherine S
Department of Veterans Affairs Medical Center, Baltimore, Maryland.
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Am J Ind Med. 2015 Jun;58(6):583-94. doi: 10.1002/ajim.22435. Epub 2015 Apr 24.
A small group of Gulf War I veterans wounded in depleted uranium (DU) friendly fire incidents have been monitored in a clinical surveillance program at the Veterans Affairs Medical Center, Baltimore since 1994.
An in-patient clinical surveillance protocol was performed on 35 members of the cohort, including exposure monitoring for total and isotopic uranium concentrations in urine and a comprehensive assessment of health outcomes.
Although urine U concentrations continue to be elevated in this group, illustrating on-going in situ mobilization of U from embedded fragments, no consistent U-related health effects have been observed.
Now more than 20 years since first exposure to DU, an aging cohort of military veterans continues to show no U-related health effects in known target organs of U toxicity. As tissue concentrations continue to accrue with exposure duration, critical tissue-specific U concentration thresholds may be reached, thus recommending on-going surveillance of this veteran cohort.
自1994年以来，一小群在海湾战争一期冲突中因友军火力造成贫铀（DU）伤害的退伍军人一直在巴尔的摩退伍军人事务医疗中心的临床监测项目中接受监测。
对该队列中的35名成员执行了住院临床监测方案，包括对尿液中总铀和同位素铀浓度的暴露监测以及对健康结果的全面评估。
尽管该组人群尿液中的铀浓度持续升高，表明嵌入碎片中的铀在持续进行原位动员，但未观察到与铀相关的一致健康影响。
自首次接触贫铀至今已过去20多年，这一老龄化的退伍军人队列在已知的铀毒性靶器官中仍未显示出与铀相关的健康影响。随着组织浓度随着暴露时间的延长而不断累积，可能会达到关键的组织特异性铀浓度阈值，因此建议对这一退伍军人队列继续进行监测。
