Glick Danielle R, Brown Clayton H, Li Lan, Gucer Patricia, Gaitens Joanna M, McDiarmid Melissa A, Hines Stella E
Division of Pulmonary and Critical Care Medicine, School of Medicine, University of Maryland, Baltimore, MD, United States.
Department of Veterans Affairs Medical Center, Baltimore, MD, United States.
Open Respir Med J. 2024 Jul 19;18:e18743064304109. doi: 10.2174/0118743064304109240611054726. eCollection 2024.
Impulse oscillometry (IOs) is a technique used to evaluate lung function that uses sound waves imposed over tidal breathing to characterize the airways and lung parenchyma. IOs has been particularly useful in the identification of obstructive lung defects. The present analysis seeks to explore the use of IOs in the identification of restrictive lung physiology among a group of Gulf War I veterans exposed to depleted uranium (DU).
A total of 36 out of a dynamic 85-veteran cohort attended in-person surveillance visits in 2019 and completed both IOs and PFTs. Performance on IOs was evaluated in a cross-sectional analysis of the group overall and in those identified as having restrictive lung defects defined by either spirometry (FEV1/FVC ≥ LLN and FVC < LLN) or lung volumes (TLC < LLN).
A total of 6 individuals were identified as having restriction (4 based on spirometry alone and an additional 2 by lung volumes). When restriction was present, IOs values of both resistance and reactance were significantly more abnormal.
In the assessment of lung function, IOs may be advantageous over PFTs because it is faster to perform and effort-independent. Although little is known about the utility of IOs in identifying restrictive lung physiology, our results support its use.
脉冲振荡法（IOs）是一种用于评估肺功能的技术，它利用叠加在潮式呼吸上的声波来表征气道和肺实质。IOs在识别阻塞性肺缺陷方面特别有用。本分析旨在探讨IOs在一组接触贫铀（DU）的海湾战争I退伍军人中识别限制性肺生理状况的应用。
在一个由85名退伍军人组成的动态队列中，共有36人参加了2019年的现场监测访问，并完成了IOs和肺功能测试（PFTs）。在对该组整体以及那些被确定为患有由肺量计（FEV1/FVC≥下限值且FVC＜下限值）或肺容量（TLC＜下限值）定义的限制性肺缺陷的人群进行横断面分析时，评估了IOs的表现。
共有6人被确定为存在限制（4人仅基于肺量计，另外2人基于肺容量）。当存在限制时，阻力和电抗的IOs值明显更异常。
在肺功能评估中，IOs可能比PFTs更具优势，因为它执行速度更快且不依赖用力。尽管关于IOs在识别限制性肺生理状况方面的效用知之甚少，但我们的结果支持其应用。
