Eisen Rebecca, Perera Stefan, Bawor Monica, Banfield Laura, Anglin Rebecca, Minuzzi Luciano, Samaan Zainab
MiNDS Neuroscience Graduate Program, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
Health Research Methodology Graduate Program, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
Syst Rev. 2015 Apr 24;4:56. doi: 10.1186/s13643-015-0047-x.
Suicide is a worldwide public health concern that claims close to 1 million lives each year. Suicidal behaviour is a significant risk factor for completed suicide and is much more prevalent than completed suicide. Many internal and external factors contribute to the risk of suicidal behaviour. Recent research has focused on biological markers in suicide risk, including brain-derived neurotrophic factor (BDNF). BDNF is a protein involved in the growth, function, and maintenance of the nervous system. It has been implicated in psychiatric disorders and suicide. While some evidence suggests that reduced levels of BDNF are associated with suicide, the precise relationship has yet to be determined. The aim of this study is to review the literature examining the relationship between levels of BDNF and suicidal behaviour.
A predefined search strategy will be implemented to search the following electronic databases: PubMed/MEDLINE, Excerpta Medica Database (EMBASE), PsycINFO, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) from inception. The articles will be screened by two independent authors (RE and SP) using predetermined inclusion and exclusion criteria. Discrepancies will be resolved by consensus, or by a third author (ZS) in cases of disagreement. The primary outcome will be the association between levels of BDNF and suicidal behaviour. A meta-analysis will be conducted if appropriate. Quality of evidence and risk of bias will be evaluated.
The findings of this review will assist in identifying and treating individuals at increased risk of suicide.
PROSPERO CRD42015015871 .
自杀是一个全球公共卫生问题，每年导致近100万人死亡。自杀行为是导致自杀死亡的一个重要风险因素，且比自杀死亡更为普遍。许多内在和外在因素都会导致自杀行为的风险。最近的研究集中在自杀风险的生物标志物上，包括脑源性神经营养因子（BDNF）。BDNF是一种参与神经系统生长、功能和维持的蛋白质。它与精神疾病和自杀有关。虽然一些证据表明BDNF水平降低与自杀有关，但确切关系尚未确定。本研究的目的是回顾研究BDNF水平与自杀行为之间关系的文献。
将实施预定义的检索策略，检索以下电子数据库：自数据库建立起的PubMed/MEDLINE、医学文摘数据库（EMBASE）、心理学文摘数据库（PsycINFO）以及护理学与健康相关文献累积索引数据库（CINAHL）。文章将由两位独立作者（RE和SP）根据预先确定的纳入和排除标准进行筛选。如有分歧，将通过协商解决，或由第三位作者（ZS）处理分歧情况。主要结果将是BDNF水平与自杀行为之间的关联。如有合适情况，将进行荟萃分析。将评估证据质量和偏倚风险。
本综述的结果将有助于识别和治疗自杀风险增加的个体。
PROSPERO CRD42015015871 。
