铜催化的烯烃分子间三氟甲基硫氰化反应：方便地得到含 CF3 的烷基硫氰酸酯。
Copper-Catalyzed Intermolecular Trifluoromethylthiocyanation of Alkenes: Convenient Access to CF3-Containing Alkyl Thiocyanates.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of OrganicChemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
出版信息
Org Lett. 2015 May 15;17(10):2438-41. doi: 10.1021/acs.orglett.5b00939. Epub 2015 Apr 24.
PMID:25908571
Abstract
A highly selective and efficient approach for the direct trifluoromethylthiocyanation of alkenes has been developed using trimethylsilyl isothiocyanate (TMSNCS) as the thiocyanating agent and Togni reagent as the CF3 source in the presence of copper(I) catalyst. Both activated and unactivated alkenes work well to deliver various CF3-containing thiocyanates.
摘要
一种高选择性和高效的方法，用于直接三氟甲基硫氰化烯烃，已经开发出来，使用三甲基硅基异硫氰酸酯（TMSNCS）作为硫氰化剂和 Togni 试剂作为 CF3 源，在铜（I）催化剂的存在下。无论是活化的还是未活化的烯烃，都能很好地转化为各种含 CF3 的硫氰酸酯。
Zotero 插件