Ota Kazumi, Murayama Norio, Kasanuki Koji, Kondo Daizo, Fujishiro Hiroshige, Arai Heii, Sato Kiyoshi, Iseki Eizo
PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Tokyo 136-0075, Japan.
PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Tokyo 136-0075, Japan Department of Health Science, School of Allied Health Sciences, Kitasato University, Kanagawa 252-0373, Japan.
Arch Clin Neuropsychol. 2015 May;30(3):256-63. doi: 10.1093/arclin/acv016.
We examined the utility of illusory contours (ICs) for the differentiation of dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). Thirty-five probable DLB patients, 35 probable AD patients controlled by age, years of education, and Mini-Mental State Examination (MMSE) score, and 30 cognitively normal subjects controlled by age and years of education underwent visuoperceptual examinations including ICs, pentagon copying in MMSE, overlapping figures, clock drawing test, cube copying, and line orientation. Four items in ICs (ICs-4) were found to be significantly impaired in DLB compared with AD, and a sensitivity and a specificity of total score of ICs-4 were 88.6% and 37.1%, respectively. When a score of ICs-4 is combined with a 10-point scaled score of pentagon copying in MMSE, a sensitivity and a specificity were 77.1% and 82.9%, respectively. The present study suggests that ICs-4 can be included in neuropsychological examinations to assess visuoperceptual impairment in DLB.
我们研究了虚幻轮廓（ICs）对于区分路易体痴呆（DLB）和阿尔茨海默病（AD）的效用。35例可能患有DLB的患者、35例在年龄、受教育年限和简易精神状态检查表（MMSE）评分方面进行了匹配的可能患有AD的患者，以及30例在年龄和受教育年限方面进行了匹配的认知正常受试者，接受了包括ICs、MMSE中的五边形临摹、重叠图形、画钟试验、立方体临摹和直线定向在内的视觉感知检查。结果发现，与AD相比，DLB患者在ICs中的四项内容（ICs-4）存在显著损害，ICs-4总分的敏感性和特异性分别为88.6%和37.1%。当将ICs-4的得分与MMSE中五边形临摹的10分制得分相结合时，敏感性和特异性分别为77.1%和82.9%。本研究表明，ICs-4可纳入神经心理学检查，以评估DLB患者的视觉感知损害。
