Physiology. Calcilytics for asthma relief.
作者信息
Penn Raymond B
机构信息
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Lung Center, Thomas Jefferson University, Philadelphia, PA, USA.
出版信息
Science. 2015 Apr 24;348(6233):398-9. doi: 10.1126/science.aab2173.
Abstract
摘要
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本文引用的文献
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Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.钙敏感受体拮抗剂可消除过敏性哮喘中的气道高反应性和炎症。
Sci Transl Med. 2015 Apr 22;7(284):284ra60. doi: 10.1126/scitranslmed.aaa0282.
2
Chloride channel blockade relaxes airway smooth muscle and potentiates relaxation by β-agonists.氯离子通道阻断可使气道平滑肌舒张，并增强β-肾上腺素能激动剂的舒张作用。
Am J Physiol Lung Cell Mol Physiol. 2014 Aug 1;307(3):L273-82. doi: 10.1152/ajplung.00351.2013. Epub 2014 May 30.
3
Can we find better bronchodilators to relieve asthma symptoms?我们能找到更好的支气管扩张剂来缓解哮喘症状吗？
J Allergy (Cairo). 2012;2012:321949. doi: 10.1155/2012/321949. Epub 2012 Oct 2.
4
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J Allergy Clin Immunol. 2011 Feb;127(2):355-60. doi: 10.1016/j.jaci.2010.11.037.
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Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.气道平滑肌上的苦味受体通过局部钙信号转导和逆转阻塞来舒张支气管。
Nat Med. 2010 Nov;16(11):1299-304. doi: 10.1038/nm.2237. Epub 2010 Oct 24.
6
Beta-2 adrenergic agonists: focus on safety and benefits versus risks.β2 肾上腺素能激动剂：关注安全性和益处与风险的关系。
Curr Opin Pharmacol. 2010 Jun;10(3):246-53. doi: 10.1016/j.coph.2010.04.009. Epub 2010 May 6.
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Real-world Evaluation of Asthma Control and Treatment (REACT): findings from a national Web-based survey.哮喘控制与治疗的真实世界评估（REACT）：一项基于网络的全国性调查结果
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