Lee Chanyoung, Richtsmeier Joan T, Kraft Reuben H
The Pennsylvania State University, State College, PA, USA.
Int Mech Eng Congress Expo. 2014 Nov;2014. doi: 10.1115/IMECE2014-38728.
Craniosynostosis is a condition defined by premature closure of cranial vault sutures, which is associated with abnormalities of the brain and skull. Many causal relationships between discovered mutations and premature suture closure have been proposed but an understanding of the precise mechanisms remains elusive. This article describes a computational framework of biological processes underlying cranial growth that will enable a hypothesis driven investigation of craniosynostosis phenotypes using reaction-diffusion-advection methods and the finite element method. Primary centers of ossification in cranial vault are found using activator-substrate model that represents the behavior of key molecules for bone formation. Biomechanical effects due to the interaction between growing bone and soft tissue is investigated to elucidate the mechanism of growth of cranial vault.
颅缝早闭是一种由颅顶骨缝过早闭合所定义的病症，它与脑和颅骨的异常有关。已提出了许多已发现的突变与过早骨缝闭合之间的因果关系，但对精确机制的理解仍然难以捉摸。本文描述了颅生长背后生物过程的计算框架，该框架将使用反应扩散对流方法和有限元方法，对颅缝早闭表型进行假设驱动的研究。使用代表骨形成关键分子行为的激活剂-底物模型来发现颅顶骨的主要骨化中心。研究生长中的骨骼与软组织之间相互作用产生的生物力学效应，以阐明颅顶骨的生长机制。
