人心脏对肌苷的明显摄取。

Apparent inosine uptake by the human heart.

作者信息

de Jong J W, Czarnecki W, Ruzyllo W, Huizer T, Herbaczyńska-Cedro K

机构信息

Cardiochemical Laboratory, Erasmus University Rotterdam, The Netherlands.

出版信息

Cardiovasc Res. 1989 Jun;23(6):484-8. doi: 10.1093/cvr/23.6.484.

DOI:10.1093/cvr/23.6.484

PMID:2590921

Abstract

Although inosine has been used clinically to support the myocardium, no data are available on the fate of exogenous inosine in the human heart. We therefore infused six patients, catheterised for coronary angiography, with inosine (5 mg.kg-1.min-1 intravenously) for 6 minutes. Before infusion, the arterio-venous difference of inosine, hypoxanthine and xanthine across the heart was nil. During infusion, arterial inosine increased substantially, exceeding the coronary sinus concentration by a maximum of 200 (SEM 53) mumol.litre-1, p = 0.02, at the fourth minute. Arterial hypoxanthine and xanthine also increased, while the arterio-venous difference became 16(11) and 10(3) (p = 0.04) mumol.litre-1, respectively. Left ventricular dP/dtmax increased by 22(7)% (p = 0.04) at the end of infusion. Thus, there seemed to be substantial uptake of inosine by the human heart, followed by improvement in haemodynamics.

摘要

尽管肌苷已在临床上用于支持心肌，但关于外源性肌苷在人心脏中的转归尚无数据。因此，我们对6例因冠状动脉造影而插入导管的患者静脉输注肌苷（5mg·kg⁻¹·min⁻¹），持续6分钟。输注前，心脏肌苷、次黄嘌呤和黄嘌呤的动静脉差值为零。输注期间，动脉血肌苷显著增加，在第4分钟时，动脉血肌苷浓度比冠状窦浓度最高高出200（标准误53）μmol·L⁻¹，p = 0.02。动脉血次黄嘌呤和黄嘌呤也增加，而动静脉差值分别变为16（11）和10（3）（p = 0.04）μmol·L⁻¹。输注结束时，左心室dp/dtmax增加了22（7）%（p = 0.04）。因此，人心脏似乎大量摄取肌苷，随后血流动力学得到改善。