Wu Y H, Wang Z Y, Lu S Q, Ji A P, Zhang C H
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1989;7(3):187-90.
Seventy-seven Meriones unguiculatus were inoculated intra-esophageal with Giardia lamblia cysts isolated from the stool of a Giardia infected child. Correlation between oral dosage, course of infection, trophozoite distribution and the pathological changes in the small intestine of the infected jirds were studied. One (12.5%) of eight animals became infected with only 5 cysts. 10(4) cysts/jird or more was infective to nearly all the animals. Most of the infected animals (83%) excreted cysts and/or trophozoites intermittently. The extent of trophozoite colonization and their distribution in the small intestine varied with the time of infection, but not with the number of Giardia found in the feces. There was no direct correlation between the size of inoculum and the course of infection, the fecal output of cysts and/or trophozoites, or the intensity of pathological changes in the small intestine. The histopathological lesions induced by G. lamblia included cellular infiltration of the mucosa of the small bowel, nodular lymphoid hyperplasia, edema of the lamina propria and increase in mucous secretion. Necrobiosis and shedding of the epithelium was evident, and the mitotic figures of intestinal crypt increased significantly. The reduction of the villi to crypts ratio may indicate that the villi of small intestine were covered by relatively immature enterocytes, which may, partially, account for the malabsorption in giardiasis (Figs. 1-3).
将从一名感染贾第虫的儿童粪便中分离出的贾第虫囊肿经食管内接种77只长爪沙鼠。研究了口服剂量、感染过程、滋养体分布与受感染长爪沙鼠小肠病理变化之间的相关性。8只动物中有1只（12.5%）仅接种5个囊肿就被感染。每只长爪沙鼠接种10（4）个囊肿或更多时，几乎所有动物都会被感染。大多数受感染动物（83%）间歇性地排出囊肿和/或滋养体。滋养体定植的程度及其在小肠中的分布随感染时间而变化，但与粪便中发现的贾第虫数量无关。接种量的大小与感染过程、囊肿和/或滋养体的粪便排出量或小肠病理变化的强度之间没有直接相关性。贾第虫引起的组织病理学病变包括小肠黏膜的细胞浸润、结节性淋巴样增生、固有层水肿和黏液分泌增加。上皮细胞的坏死和脱落明显，肠隐窝的有丝分裂象显著增加。绒毛与隐窝比值的降低可能表明小肠绒毛被相对不成熟的肠上皮细胞覆盖，这可能部分解释了贾第虫病中的吸收不良（图1 - 3）。
