Makled M K, Abbas M M, Abou el Seoud S F, Ismail A K
Department of Parasitology and Pathology, Faculty of Medicine, Ain Shams University, Abbassia, Cairo.
J Egypt Soc Parasitol. 1994 Apr;24(1):205-10.
This study was done to evaluate the pathological effects of Giardia lamblia cysts obtained from immunosuppressed host on the small intestine and liver of immunocompetent hosts. Thirty mice, subdivided into two groups, were infected with G. lamblia cysts in a dose of 5000 cysts/mouse. The first group (10 mice) was inoculated with Giardia cysts obtained from immunocompetent patients and the second group (20 mice) was inoculated with Giardia cysts obtained from already immunosuppressed mice (injected with cyclophosphamide). Stool examination revealed that mice in both groups passed cysts on day 6 +/- 1 after infection. The pathological changes of small intestine in both groups were more or less similar. The changes were in the form of shortening and widening of the villi with cellular inflammatory infiltrate in the lamina propria. The liver of both groups showed no pathological changes. It can be concluded that, although immunosuppression affects the immune system and the defensive mechanism of the host, yet it has no effects on the virulence of the excreted Giardia lamblia cysts.
本研究旨在评估从免疫抑制宿主获得的蓝氏贾第鞭毛虫囊肿对免疫功能正常宿主的小肠和肝脏的病理影响。将30只小鼠分为两组，以每只小鼠5000个囊肿的剂量感染蓝氏贾第鞭毛虫囊肿。第一组（10只小鼠）接种从免疫功能正常患者获得的贾第虫囊肿，第二组（20只小鼠）接种从已免疫抑制的小鼠（注射环磷酰胺）获得的贾第虫囊肿。粪便检查显示，两组小鼠在感染后第6±1天排出囊肿。两组小肠的病理变化大致相似。变化表现为绒毛缩短、变宽，固有层有细胞炎性浸润。两组肝脏均未显示病理变化。可以得出结论，虽然免疫抑制会影响宿主的免疫系统和防御机制，但对排出的蓝氏贾第鞭毛虫囊肿的毒力没有影响。
