原发性纤维肌痛患者神经肌肉兴奋性增高特征的证据。

Evidence of neuromuscular hyperexcitability features in patients with primary fibromyalgia.

作者信息

Vitali C, Tavoni A, Rossi B, Bibolotti E, Giannini C, Puzzuoli L, Cacialli R, Pasero G

机构信息

Rheumatic Disease Unit, University of Pisa, Italy.

出版信息

Clin Exp Rheumatol. 1989 Jul-Aug;7(4):385-90.

PMID:2591111

Abstract

The presence of clinical and electromyographic (EMG) features of neuromuscular hyperexcitability (NMHE) and of the commonly associated neurovegetative disturbances (NVD) were investigated in 49 patients with primary fibromyalgia (PF) and in a control group of 33 patients with rheumatoid arthritis (RA). At least two clinical features of NMHE were present in 39%, and at least three NVD in 63% of PF patients. In contrast, only 1 RA control had two NMHE features (p greater than 0.005) and three NVD (p less than 0.001). Moreover, a significant post-ischemic spontaneous EMG hyperactivity was observed in 11 PF patients, and in only 1 control with RA (p less than 0.05). Finally, in patients with PF the number of tender points were correlated with psychological tests for depression (p less than 0.02), and the number of NVD. The present study shows that in patients with PF there is a large prevalence of NMHE complaints and NVD. The potential underlying pathogenetic mechanisms are also discussed.

摘要

对49例原发性纤维肌痛（PF）患者及33例类风湿关节炎（RA）患者组成的对照组进行了研究，以调查神经肌肉兴奋性过高（NMHE）的临床和肌电图（EMG）特征以及常见的相关自主神经功能紊乱（NVD）情况。39%的PF患者存在至少两种NMHE临床特征，63%的PF患者存在至少三种NVD。相比之下，RA对照组中只有1例有两种NMHE特征（p>0.005），3例有三种NVD（p<0.001）。此外，11例PF患者出现明显的缺血后自发性肌电图活动亢进，而RA对照组中只有1例出现（p<0.05）。最后，PF患者的压痛点数量与抑郁心理测试结果（p<0.02）以及NVD数量相关。本研究表明，PF患者中NMHE症状和NVD的患病率很高。同时还讨论了潜在的发病机制。