Öztürk Hakan
Department of Urology, School of Medicine, Sifa University, Izmir, Turkey.
Int J Surg Case Rep. 2015;11:33-36. doi: 10.1016/j.ijscr.2015.04.017. Epub 2015 Apr 14.
Metachronous penile metastasis of bladder cancer occurs very rarely. The clinical management of the disease involves complex problems, and the disease is associated with a poor prognosis. The common mode of spread to the penis is by the retrograde venous route.
A 68-year-old patient who was diagnosed with invasive bladder cancer underwent (18)F-fluorodeoxyglucose (FDG)-positron-emission tomography/computed tomography (PET/CT) for staging purposes. An 18mm intracavernosal metastatic lesion was detected in the penis with a SUVmax of 12.9.
After the administration of gemcitabine+cisplatin-based chemotherapy, remission was observed in the metastatic penile lesion according to EORTC criteria (12mm, SUVmax: 9), and second line chemotherapy program was planned.
Penile metastasis from bladder cancer is an indicator of poor prognosis. The patients with penile metastasis poorly respond to therapy, despite the use of effective systemic chemotherapy. The researchers of the current study achieved a partial response to chemotherapy in the current case of penile metastasis. The disease-specific life expectancy is less than one year in these patients. Radical ablative surgery does not contribute to survival; however, it offers an alternative method in symptomatic patients.
膀胱癌异时性阴茎转移极为罕见。该疾病的临床管理涉及复杂问题，且预后较差。其转移至阴茎的常见途径是逆行静脉途径。
一名68岁被诊断为浸润性膀胱癌的患者接受了（18）F - 氟脱氧葡萄糖（FDG） - 正电子发射断层扫描/计算机断层扫描（PET/CT）以进行分期。阴茎海绵体内发现一个18毫米的转移病灶，最大标准摄取值（SUVmax）为12.9。
给予吉西他滨 + 顺铂为基础的化疗后, 根据欧洲癌症研究与治疗组织（EORTC）标准，转移的阴茎病灶出现缓解（12毫米，SUVmax：9），并计划了二线化疗方案。
膀胱癌阴茎转移是预后不良的指标。尽管使用了有效的全身化疗，阴茎转移患者对治疗反应不佳。本研究的研究人员在当前阴茎转移病例中实现了化疗的部分缓解。这些患者的疾病特异性预期寿命不到一年。根治性切除手术对生存无帮助；然而，它为有症状的患者提供了一种替代方法。
