Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Mass.
Social and Occupational Determinants of Health, INSERM Centre for Research in Epidemiology and Population Health, Villejuif, France; Université de Versailles St-Quentin, UMRS 1018, Versailles, France.
Am J Med. 2015 Sep;128(9):1023.e33-9. doi: 10.1016/j.amjmed.2015.04.011. Epub 2015 Apr 23.
Restless legs syndrome has been speculated to be linked to cognitive impairment through vascular risk factors or through its effect on sleep deprivation. Previous studies on the association between restless legs syndrome and cognitive function have been inconclusive. We performed a cross-sectional analysis of the association between restless legs syndrome and cognitive function using data from a large population-based study of elderly individuals residing in France.
We used information from 2070 individuals from the Dijon, France center of the Three-City study who had available information on restless legs syndrome and cognitive functioning measures. Restless legs syndrome was assessed using the 4 minimal diagnostic criteria of the International Restless Legs Study Group. During the same wave in which restless legs syndrome status was assessed, cognitive functions also were assessed using 4 tests: Isaacs' test of verbal/category fluency, the Benton Visual Retention Test, the Trail Making Test B, and the Mini-Mental State Examination. We created a summary global cognitive score by summing the z scores for the 4 tests and used analysis of covariance to explore the association between restless legs syndrome and cognitive function.
We did not observe any statistically significant differences in any cognitive z-score between those with restless legs syndrome and those without restless legs syndrome. The mean global z-score after multivariate adjustment was -0.003 (SE 0.173) for those with restless legs syndrome and -0.007 (SE 0.129) for those without restless legs syndrome (P-value = .98).
Data from this large, population-based study do not suggest that restless legs syndrome is associated with prevalent cognitive deficits in elderly individuals.
不宁腿综合征被认为与血管危险因素或睡眠剥夺有关，从而导致认知障碍。既往关于不宁腿综合征与认知功能之间关系的研究结果并不一致。我们利用一项针对居住在法国的老年人群的大型基于人群的研究数据，进行了横断面分析，以评估不宁腿综合征与认知功能之间的关系。
我们使用了来自法国第戎市三城研究中心的 2070 名个体的信息，这些个体具有不宁腿综合征和认知功能测量的相关信息。不宁腿综合征采用国际不宁腿研究组的 4 项最低诊断标准进行评估。在评估不宁腿综合征状态的同一波次中，还使用 4 项测试评估认知功能：Isaacs 言语/类别流畅性测试、本顿视觉保留测试、连线测试 B 和简易精神状态检查。我们通过将 4 项测试的 z 分数相加来创建一个综合的总体认知评分，并使用协方差分析来探索不宁腿综合征与认知功能之间的关系。
我们未观察到患有不宁腿综合征和不患有不宁腿综合征的个体之间任何认知 z 分数存在统计学显著差异。经多变量调整后，患有不宁腿综合征的个体的平均总体 z 分数为-0.003（SE 0.173），而不患有不宁腿综合征的个体的平均总体 z 分数为-0.007（SE 0.129）（P 值=.98）。
这项大型基于人群的研究的数据表明，不宁腿综合征与老年个体中普遍存在的认知缺陷无关。
