Hanewinckel Rens, Maksimovic Ana, Verlinden Vincent J A, van der Geest Jos N, Hofman Albert, van Doorn Pieter A, Boon Agnita J W, Tiemeier Henning, Ikram M Arfan
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Sleep Med. 2015 Mar;16(3):399-405. doi: 10.1016/j.sleep.2014.11.013. Epub 2015 Jan 14.
To investigate whether restless legs syndrome (RLS) is associated with impaired physical functioning using subjective and objective assessments.
From 2006-2013, 5,960 participants (mean age 67.2; 57.5% females) of the prospective population-based Rotterdam Study, aged 45 years and over, were cross-sectionally investigated for presence of restless legs syndrome using a questionnaire. Physical functioning was assessed subjectively with the Stanford Health Assessment Questionnaire (basic activities of daily living) and the Instrumental Activities of Daily living scale (instrumental activities of daily living). Additionally, physical functioning was assessed objectively by quantifying fine motor performance with the Purdue Pegboard Test and by quantifying gait with an electronic walkway.
Restless legs syndrome was present in 13.7% of the participants. Persons with restless legs had more impairment in basic (difference in score 0.65, 95% CI 0.41;0.90) and instrumental activities of daily living (difference in score 0.28, 95% CI 0.09;0.48) than persons without restless legs. This association was strongest when symptoms were present two or more times a week (basic activities of daily living score difference 1.69, 95% CI 1.28;2.09). The association between restless legs syndrome and activities of daily living attenuated after adjusting for sleep quality or depressive symptoms. There was no association with the Purdue Pegboard Test score nor with gait.
Individuals with restless legs syndrome experienced significantly more impairment in activities of daily function than persons without restless legs. This seemed to be (partly) mediated by poor sleep quality and depressive symptoms. No association was found with objectively assessed physical functioning.
采用主观和客观评估方法，调查不宁腿综合征（RLS）是否与身体功能受损有关。
在2006年至2013年期间，对基于鹿特丹前瞻性人群研究中年龄在45岁及以上的5960名参与者（平均年龄67.2岁；57.5%为女性）进行横断面调查，使用问卷来确定是否存在不宁腿综合征。使用斯坦福健康评估问卷（日常生活基本活动）和日常生活工具性活动量表（日常生活工具性活动）对身体功能进行主观评估。此外，通过普渡钉板测试量化精细运动表现，并通过电子步道量化步态，对身体功能进行客观评估。
13.7%的参与者存在不宁腿综合征。与没有不宁腿的人相比，不宁腿患者在日常生活基本活动（得分差异0.65，95%可信区间0.41；0.90）和日常生活工具性活动（得分差异0.28，95%可信区间0.09；0.48）方面的受损情况更严重。当症状每周出现两次或更多次时，这种关联最为强烈（日常生活基本活动得分差异1.69，95%可信区间1.28；2.09）。在调整睡眠质量或抑郁症状后，不宁腿综合征与日常生活活动之间的关联减弱。与普渡钉板测试得分和步态均无关联。
与没有不宁腿的人相比，不宁腿综合征患者在日常功能活动方面的受损情况明显更严重。这似乎（部分）是由睡眠质量差和抑郁症状介导的。未发现与客观评估的身体功能存在关联。
