Feng Bo, Tang Yang-Shun, Chen Bin, Xu Zheng-Hao, Wang Yi, Wu Deng-Chang, Zhao Hua-Wei, Zhang Shi-Hong, Chen Zhong
Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Neurosci Bull. 2015 Jun;31(3):297-306. doi: 10.1007/s12264-014-1524-2. Epub 2015 Apr 26.
Prospective and experimental studies have shown that individuals with early-life complex/prolonged febrile seizures (FSs) have a high incidence of temporal lobe epilepsy during adulthood, revealing a close relationship between FSs and epilepsy. However, little is known about how epileptogenesis develops after FSs. The present study was designed to investigate acquired seizure susceptibility and analyze local field potentials during the latent period after FSs. We found that the seizure susceptibility decreased in 35-day-old (P35) FS rats but increased in P60 FS rats. Consistently, hippocampal electroencephalogram (EEG) power in every band was decreased at P35 but increased at P60 in FS rats. Our results provide direct evidence for hypoactivity but not hyperactivity during the early phase of the latent period, displaying a broad decrease in hippocampal rhythms. These characteristic EEG changes can be a useful biomarker for the early diagnosis of epileptogenesis induced by FSs.
前瞻性和实验性研究表明，早年患有复杂性/长时间热性惊厥（FSs）的个体在成年期患颞叶癫痫的发生率很高，这揭示了FSs与癫痫之间的密切关系。然而，关于FSs后癫痫发生的发展过程却知之甚少。本研究旨在调查获得性癫痫易感性，并分析FSs后潜伏期的局部场电位。我们发现，35日龄（P35）的FS大鼠癫痫易感性降低，但P60的FS大鼠癫痫易感性增加。同样，FS大鼠海马脑电图（EEG）各频段的功率在P35时降低，但在P60时增加。我们的结果为潜伏期早期的活动减退而非活动亢进提供了直接证据，表现为海马节律广泛降低。这些特征性的脑电图变化可能是FSs诱发癫痫发生早期诊断的有用生物标志物。
