Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Department of Neurology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China.
Int J Mol Sci. 2023 Jan 20;24(3):2039. doi: 10.3390/ijms24032039.
Status epilepticus (SE), a condition with abnormally prolonged seizures, is a severe type of epilepsy. At present, SE is not well controlled by clinical treatments. Antiepileptic drugs (AEDs) are the main therapeutic approaches, but they are effective for SE only with a narrow intervening window, and they easily induce resistance. Thus, in this review, we provide an updated summary for an insight into drug-resistant SE, hoping to add to the understanding of the mechanism of refractory SE and the development of active compounds. Firstly, we briefly outline the limitations of current drug treatments for SE by summarizing the extensive experimental literature and clinical data through a search of the PubMed database, and then summarize the common animal models of refractory SE with their advantages and disadvantages. Notably, we also briefly review some of the hypotheses about drug resistance in SE that are well accepted in the field, and furthermore, put forward future perspectives for follow-up research on SE.
癫痫持续状态（SE）是一种异常延长的癫痫发作状态，是一种严重的癫痫类型。目前，临床治疗对 SE 的控制效果不佳。抗癫痫药物（AEDs）是主要的治疗方法，但它们的作用有效时间窗口较窄，且容易产生耐药性。因此，在本综述中，我们提供了耐药性 SE 的最新总结，以期深入了解难治性 SE 的机制和活性化合物的开发。首先，我们通过搜索 PubMed 数据库，总结了广泛的实验文献和临床数据，简要概述了目前 SE 药物治疗的局限性，然后总结了常见的难治性 SE 动物模型及其优缺点。值得注意的是，我们还简要回顾了该领域中一些被广泛接受的关于 SE 耐药性的假说，并进一步提出了 SE 后续研究的未来展望。
