Boccia Maddalena, D'Amico Simonetta, Bianchini Filippo, Marano Assunta, Giannini Anna Maria, Piccardi Laura
Neuropsychology Unit, IRCCS Fondazione Santa Lucia of Rome, Rome, Italy.
Department of Psychology, "Sapienza" University of Rome, Via dei Marsi, 78, 00185, Rome, Italy.
Brain Imaging Behav. 2016 Mar;10(1):226-37. doi: 10.1007/s11682-015-9387-3.
Post-traumatic stress disorder (PTSD) is an anxiety condition that can develop after exposure to trauma such as physical or sexual assault, injury, combat-related trauma, natural disaster or death. Although an increasing number of neurobiological studies carried out over the past 20 years have allowed clarifying the neural substrate of PTSD, the neural modifications underpinning PTSD are still unclear. Here we used activation likelihood estimation meta-analysis (ALE) to determine whether PTSD has a consistent neural substrate. We also explored the possibility that different traumatic events produce different alterations in the PTSD neural network. In neuroimaging studies of PTSD, we found evidence of a consistent neural network including the bilateral insula and cingulate cortex as well as the parietal, frontal and limbic areas. We also found that specific networks of brain areas underpin PTSD after different traumatic events and that these networks may be related to specific aspects of the traumatic events. We discuss our results in light of the functional segregation of the brain areas involved in PTSD.
创伤后应激障碍（PTSD）是一种焦虑症，可在遭受身体或性侵犯、受伤、与战斗相关的创伤、自然灾害或死亡等创伤后发生。尽管在过去20年中进行的越来越多的神经生物学研究已经能够阐明PTSD的神经基础，但支撑PTSD的神经改变仍不清楚。在这里，我们使用激活可能性估计元分析（ALE）来确定PTSD是否具有一致的神经基础。我们还探讨了不同创伤事件在PTSD神经网络中产生不同改变的可能性。在PTSD的神经影像学研究中，我们发现了一个一致的神经网络的证据，包括双侧脑岛和扣带回皮质以及顶叶、额叶和边缘区域。我们还发现，不同创伤事件后，特定的脑区网络支撑着PTSD，并且这些网络可能与创伤事件的特定方面有关。我们根据参与PTSD的脑区的功能分离来讨论我们的结果。
