Zhang Youxue, Liu Feng, Chen Heng, Li Meiling, Duan Xujun, Xie Bing, Chen Huafu
Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.
Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China; Department of Anatomy, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China.
J Affect Disord. 2015 Nov 15;187:114-21. doi: 10.1016/j.jad.2015.08.043. Epub 2015 Aug 22.
A large number of previous neuroimaging studies have explored the functional alterations of post-traumatic stress disorder (PTSD). However, abnormalities in the functional architecture of resting-state networks in PTSD were rarely elucidated.
This study used independent component analysis to explore the resting-state intranetwork and internetwork functional connectivity differences between 20 PTSD patients and 20 matched healthy controls (HCs).
Selective alterations of intranetwork and internetwork intrinsic functional connectivities were found in the PTSD patients. Compared with HCs, the PTSD patients exhibited significantly decreased network connectivity within the anterior default mode network, posterior default mode network (pDMN), salience network (SN), sensory-motor network, and auditory network. Furthermore, the PTSD patients exhibited increased internetwork connectivity between SN and pDMN.
This study lacked recruitment of trauma-exposed HCs, which limits our ability to determine whether the alterations are caused by PTSD or trauma exposure.
The findings suggested that the PTSD patients exhibited abnormal functional connectivity at the brain network level. Notably, the enhanced internetwork connectivity between SN and pDMN in the PTSD patients may be associated with hyperarousal and heightened anxiety in PTSD.
此前大量神经影像学研究探讨了创伤后应激障碍（PTSD）的功能改变。然而，PTSD静息态网络功能结构的异常鲜有阐明。
本研究采用独立成分分析，探究20例PTSD患者与20例匹配的健康对照（HCs）之间静息态网络内和网络间的功能连接差异。
在PTSD患者中发现了网络内和网络间固有功能连接的选择性改变。与HCs相比，PTSD患者在前默认模式网络、后默认模式网络（pDMN）、突显网络（SN）、感觉运动网络和听觉网络内的网络连接显著降低。此外，PTSD患者SN与pDMN之间的网络间连接增加。
本研究未纳入经历过创伤的HCs，这限制了我们确定这些改变是由PTSD还是创伤暴露所致的能力。
研究结果表明，PTSD患者在脑网络水平表现出异常的功能连接。值得注意的是，PTSD患者SN与pDMN之间增强的网络间连接可能与PTSD中的过度觉醒和焦虑加剧有关。
