van Erp Paul Bg, Bloomer Gary, Wilkinson Royce, Wiedenheft Blake
Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA.
Technology Transfer Office, Montana State University, Bozeman, MT 59717, USA.
Curr Opin Virol. 2015 Jun;12:85-90. doi: 10.1016/j.coviro.2015.03.011. Epub 2015 Apr 26.
The interface between viruses and their hosts' are hot spots for biological and biotechnological innovation. Bacteria use restriction endonucleases to destroy invading DNA, and industry has exploited these enzymes for molecular cut-and-paste reactions that are central to many recombinant DNA technologies. Today, another class of nucleases central to adaptive immune systems that protect bacteria and archaea from invading viruses and plasmids are blazing a similar path from basic science to profound biomedical and industrial applications.
病毒与其宿主之间的界面是生物学和生物技术创新的热点。细菌利用限制性内切核酸酶来破坏入侵的DNA，而工业界已利用这些酶进行分子切割和粘贴反应，这些反应是许多重组DNA技术的核心。如今，另一类在适应性免疫系统中起核心作用的核酸酶正引领着从基础科学到深远的生物医学和工业应用的相似道路，这类核酸酶可保护细菌和古生菌免受入侵病毒和质粒的侵害。
