Varrone Andrea, Svenningsson Per, Marklund Petter, Fatouros-Bergman Helena, Forsberg Anton, Halldin Christer, Nilsson Lars-Göran, Farde Lars
Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Stockholm, Sweden.
Stockholm Brain Institute, Stockholm, Sweden.
Synapse. 2015 Jul;69(7):365-74. doi: 10.1002/syn.21823. Epub 2015 May 25.
The serotonin 5-HT1B receptor subtype is involved in the modulation of serotonin release and is a target of interest for neuroreceptor imaging. Previous studies have shown that the serotonin system is affected in Parkinson's disease (PD). Cognitive function, frequently impaired in PD, has been linked to the serotonin system. The aim of this study was to examine whether 5-HT1B receptor availability in the brain of healthy subjects and PD patients is associated with measures of cognitive function.
Twelve control subjects and ten PD patients with normal mini-mental state examination scores were included in this study. Cognitive function was evaluated by assessment of semantic, episodic, and working memory, as well as fluency and visual attention. Creative ability, a measure of divergent thinking, was examined with the alternative uses of objects task. PET measurements were performed with the 5-HT1B receptor-radioligand [(11) C]AZ10419369 using the HRRT system.
PD patients showed statistically significant lower measures of semantic and episodic memory, as well as creative ability, compared with control subjects. Statistically significant positive correlations were found in control subjects between creative ability and average 5-HT1B receptor availability in grey matter, and in PD patients between scores of Beck Depression Inventory-II and creative ability.
Though creativity has been conventionally linked to dopamine function, our findings in control subjects suggest a link between 5-HT1B receptor availability and creative ability. In PD patients, creative ability was significantly associated with depressive symptoms but not with 5-HT1B receptor availability. This finding deserves further investigation in future studies.
血清素5-HT1B受体亚型参与血清素释放的调节，是神经受体成像感兴趣的靶点。先前的研究表明，血清素系统在帕金森病（PD）中受到影响。PD中经常受损的认知功能与血清素系统有关。本研究的目的是检查健康受试者和PD患者大脑中5-HT1B受体的可用性是否与认知功能指标相关。
本研究纳入了12名对照受试者和10名简易精神状态检查评分正常的PD患者。通过评估语义、情景和工作记忆以及流畅性和视觉注意力来评估认知功能。用物体替代用途任务检查作为发散性思维指标的创造力。使用HRRT系统，用5-HT1B受体放射性配体[(11)C]AZ10419369进行PET测量。
与对照受试者相比，PD患者在语义和情景记忆以及创造力方面的测量结果在统计学上显著较低。在对照受试者中，创造力与灰质中5-HT1B受体的平均可用性之间存在统计学上显著的正相关，在PD患者中，贝克抑郁量表-II评分与创造力之间存在统计学上显著的正相关。
虽然创造力传统上与多巴胺功能有关，但我们在对照受试者中的发现表明5-HT1B受体可用性与创造力之间存在联系。在PD患者中，创造力与抑郁症状显著相关，但与5-HT1B受体可用性无关。这一发现值得在未来的研究中进一步探讨。
