Kocabicak Ersoy, Temel Yasin, Höllig Anke, Falkenburger Björn, Tan Sonny Kh
Department of Neurosurgery, Maastricht University Medical Centre, Maastricht, the Netherlands ; Department of Neuroscience, Maastricht University, Maastricht, the Netherlands ; Department of Neurosurgery, Ondokuz Mayıs University, Samsun, Turkey.
Department of Neurosurgery, Maastricht University Medical Centre, Maastricht, the Netherlands ; Department of Neuroscience, Maastricht University, Maastricht, the Netherlands.
Neuropsychiatr Dis Treat. 2015 Apr 9;11:1051-66. doi: 10.2147/NDT.S46583. eCollection 2015.
Deep brain stimulation (DBS) has become a well-accepted therapy to treat movement disorders, including Parkinson's disease, essential tremor, and dystonia. Long-term follow-up studies have demonstrated sustained improvement in motor symptoms and quality of life. DBS offers the opportunity to selectively modulate the targeted brain regions and related networks. Moreover, stimulation can be adjusted according to individual patients' demands, and stimulation is reversible. This has led to the introduction of DBS as a treatment for further neurological and psychiatric disorders and many clinical studies investigating the efficacy of stimulating various brain regions in order to alleviate severe neurological or psychiatric disorders including epilepsy, major depression, and obsessive-compulsive disorder. In this review, we provide an overview of accepted and experimental indications for DBS therapy and the corresponding anatomical targets.
深部脑刺激（DBS）已成为一种被广泛接受的治疗运动障碍的方法，包括帕金森病、特发性震颤和肌张力障碍。长期随访研究表明，运动症状和生活质量得到持续改善。DBS提供了选择性调节目标脑区和相关神经网络的机会。此外，刺激可以根据个体患者的需求进行调整，并且刺激是可逆的。这使得DBS被引入用于治疗更多的神经和精神疾病，并且有许多临床研究在探究刺激不同脑区以缓解包括癫痫、重度抑郁症和强迫症在内的严重神经或精神疾病的疗效。在本综述中，我们概述了DBS治疗的公认和实验性适应症以及相应的解剖学靶点。
