Takahashi Kayo, Mizuno Kei, Sasaki Akihiro T, Wada Yasuhiro, Tanaka Masaaki, Ishii Akira, Tajima Kanako, Tsuyuguchi Naohiro, Watanabe Kyosuke, Zeki Semir, Watanabe Yasuyoshi
Pathophysiological and Health Science Team, RIKEN Center for Life Science Technologies Kobe, Japan ; Department of Physiology, Osaka City University Graduate School of Medicine Osaka, Japan.
Pathophysiological and Health Science Team, RIKEN Center for Life Science Technologies Kobe, Japan ; Department of Medical Science on Fatigue, Osaka City University Graduate School of Medicine Osaka, Japan ; Osaka City University Center for Health Science Innovation Osaka, Japan.
Front Hum Neurosci. 2015 Apr 9;9:191. doi: 10.3389/fnhum.2015.00191. eCollection 2015.
Using [(11)C]raclopride, a dopamine D2/D3 receptor antagonist, we undertook a positron emission tomography (PET) study to investigate the involvement of the dopaminergic neurotransmitter system when subjects viewed the pictures of partners to whom they were romantically attached. Ten subjects viewed pictures of their romantic partners and, as a control, of friends of the same sex for whom they had neutral feelings during the PET study. We administered [(11)C]raclopride to subjects using a timing for injecting the antagonist which had been determined in previous studies to be optimal for detecting increases in the amount of dopamine released by stimulation. The results demonstrated statistically significant activation of the dopaminergic system in two regions, the medial orbitofrontal cortex (mOFC) and medial prefrontal cortex, the former of which has been strongly implicated in a variety of rewarding experiences, including that of beauty and love. A positive correlation was obtained in mOFC between excitement levels and dopaminergic activation only in the love but not in the control condition.
我们使用多巴胺D2/D3受体拮抗剂[（11）C]雷氯必利进行了一项正电子发射断层扫描（PET）研究，以调查当受试者观看他们热恋对象的照片时多巴胺能神经递质系统的参与情况。10名受试者在PET研究期间观看了他们热恋对象的照片，作为对照，还观看了他们对其有中性情感的同性朋友的照片。我们按照之前研究确定的、对检测刺激释放的多巴胺量增加最为理想的拮抗剂注射时间，给受试者注射[（11）C]雷氯必利。结果显示，多巴胺能系统在两个区域有统计学意义的激活，即内侧眶额皮质（mOFC）和内侧前额叶皮质，其中前者与包括美感和爱情在内的各种奖励体验密切相关。仅在爱情条件下，mOFC中兴奋水平与多巴胺能激活之间存在正相关，而在对照条件下则不存在。
