Ciotu I M, Stoian I, Gaman L, Popescu M V, Atanasiu V
Biochemistry Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Department of Ophthalmology, Emergency Hospital Bucharest, Romania.
J Med Life. 2015 Jan-Mar;8(1):28-31.
Glaucoma is the second cause of blindness worldwide. This disease is a neurodegenerative disorder characterized by high intraocular pressure, loss of retinal ganglion cells (apoptosis). Even though there is much research done in this field, the results have not yet managed to stop the progression of glaucoma or to heal this pathology. Free oxygen radicals play a major role; they are formed in the aqueous humor and in the vitreous and they produce apoptosis of the neurons in the optic nerve head, degradation of the trabecular meshwork cells. The purpose of the article is to help in trying to understand the physiopathology of glaucoma and the efficacy of its treatments.
青光眼是全球第二大致盲原因。这种疾病是一种神经退行性疾病，其特征为眼内压升高、视网膜神经节细胞丧失（凋亡）。尽管该领域已开展了大量研究，但研究结果仍未能阻止青光眼的进展或治愈这种病症。游离氧自由基起主要作用；它们在房水和玻璃体中形成，并导致视神经乳头处的神经元凋亡、小梁网细胞降解。本文的目的是帮助人们尝试理解青光眼的病理生理学及其治疗效果。
