Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore.
Biomolecules. 2020 Apr 22;10(4):645. doi: 10.3390/biom10040645.
There is limited understanding of the specific role of high-density lipoprotein cholesterol (HDL-C) in the development of various age-related ocular diseases, despite it being a common measurable biomarker in lipid profiles. This literature review summarizes current knowledge of the role of HDL-C, if any, in pathogenesis and progression of four age-related ocular diseases, namely age-related macular degeneration (AMD), age-related cataract, glaucoma, and diabetic retinopathy (DR), and will primarily discuss epidemiological and genetic evidence.
尽管高密度脂蛋白胆固醇（HDL-C）是脂质谱中常见的可衡量生物标志物，但人们对其在各种与年龄相关的眼部疾病发展中的具体作用知之甚少。本文献综述总结了 HDL-C 在四种与年龄相关的眼部疾病（即年龄相关性黄斑变性（AMD）、年龄相关性白内障、青光眼和糖尿病性视网膜病变（DR））的发病机制和进展中是否具有作用的现有知识，主要讨论了流行病学和遗传学证据。
