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细胞起源与网络信息。

Origin of cells and network information.

作者信息

Tanabe Shihori

机构信息

Shihori Tanabe, National Institute of Health Sciences, Tokyo 158-8501, Japan.

出版信息

World J Stem Cells. 2015 Apr 26;7(3):535-40. doi: 10.4252/wjsc.v7.i3.535.

DOI:10.4252/wjsc.v7.i3.535
PMID:25914760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4404388/
Abstract

All cells are derived from one cell, and the origin of different cell types is a subject of curiosity. Cells construct life through appropriately timed networks at each stage of development. Communication among cells and intracellular signaling are essential for cell differentiation and for life processes. Cellular molecular networks establish cell diversity and life. The investigation of the regulation of each gene in the genome within the cellular network is therefore of interest. Stem cells produce various cells that are suitable for specific purposes. The dynamics of the information in the cellular network changes as the status of cells is altered. The components of each cell are subject to investigation.

摘要

所有细胞都起源于一个细胞,不同细胞类型的起源是一个令人好奇的课题。细胞在发育的每个阶段通过适时的网络构建生命。细胞间通讯和细胞内信号传导对于细胞分化和生命过程至关重要。细胞分子网络建立了细胞多样性和生命。因此,研究细胞网络中基因组内每个基因的调控是很有意义的。干细胞产生适合特定目的的各种细胞。随着细胞状态的改变,细胞网络中信息的动态也会发生变化。每个细胞的组成成分都有待研究。

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本文引用的文献

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A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis.非经典卷曲蛋白 2 信号通路调控上皮间质转化和转移。
Cell. 2014 Nov 6;159(4):844-56. doi: 10.1016/j.cell.2014.10.032.
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Promoter methylation-mediated silencing of β-catenin enhances invasiveness of non-small cell lung cancer and predicts adverse prognosis.β-连环蛋白启动子甲基化介导的沉默增强非小细胞肺癌的侵袭性并预示不良预后。
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Endothelin A receptor/β-arrestin signaling to the Wnt pathway renders ovarian cancer cells resistant to chemotherapy.内皮素 A 受体/β-arrestin 信号转导至 Wnt 通路使卵巢癌细胞对化疗产生耐药性。
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MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma.微小RNA-9通过抑制食管鳞状细胞癌中的E-钙黏蛋白促进肿瘤转移。
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Network based meta-analysis prediction of microenvironmental relays involved in stemness of human embryonic stem cells.基于网络的人类胚胎干细胞干性相关微环境信号转导的荟萃分析预测
PeerJ. 2014 Oct 23;2:e618. doi: 10.7717/peerj.618. eCollection 2014.
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Cell-based therapy approaches: the hope for incurable diseases.基于细胞的治疗方法:攻克不治之症的希望。
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Morphological analysis of human induced pluripotent stem cells during induced differentiation and reverse programming.人诱导多能干细胞在诱导分化和重编程过程中的形态学分析
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