• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Signaling involved in stem cell reprogramming and differentiation.干细胞重编程和分化过程中涉及的信号传导。
World J Stem Cells. 2015 Aug 26;7(7):992-8. doi: 10.4252/wjsc.v7.i7.992.
2
Robust Differentiation of mRNA-Reprogrammed Human Induced Pluripotent Stem Cells Toward a Retinal Lineage.mRNA重编程的人类诱导多能干细胞向视网膜谱系的稳健分化
Stem Cells Transl Med. 2016 Apr;5(4):417-26. doi: 10.5966/sctm.2015-0093. Epub 2016 Mar 1.
3
Concise Review: Reprogramming, Behind the Scenes: Noncanonical Neural Stem Cell Signaling Pathways Reveal New, Unseen Regulators of Tissue Plasticity With Therapeutic Implications.简要综述：重编程，幕后故事：非经典神经干细胞信号通路揭示了具有治疗意义的组织可塑性新的、未被发现的调节因子。
Stem Cells Transl Med. 2015 Nov;4(11):1251-7. doi: 10.5966/sctm.2015-0105. Epub 2015 Sep 14.
4
Incomplete cellular reprogramming of colorectal cancer cells elicits an epithelial/mesenchymal hybrid phenotype.结直肠癌细胞不完全的细胞重编程会引发上皮/间充质混合表型。
J Biomed Sci. 2018 Jul 19;25(1):57. doi: 10.1186/s12929-018-0461-1.
5
Reprogramming of Keratinocytes as Donor or Target Cells Holds Great Promise for Cell Therapy and Regenerative Medicine.重编程角质形成细胞作为供体细胞或靶细胞为细胞治疗和再生医学带来了巨大的希望。
Stem Cell Rev Rep. 2019 Oct;15(5):680-689. doi: 10.1007/s12015-019-09900-8.
6
Genome-wide gene expression analyses reveal unique cellular characteristics related to the amenability of HPC/HSCs into high-quality induced pluripotent stem cells.全基因组基因表达分析揭示了与造血祖细胞/造血干细胞向高质量诱导多能干细胞转化的易感性相关的独特细胞特征。
Stem Cell Res Ther. 2016 Mar 15;7:40. doi: 10.1186/s13287-016-0298-z.
7
DNA methylation in cell differentiation and reprogramming: an emerging systematic view.细胞分化和重编程中的 DNA 甲基化：一种新兴的系统观点。
Regen Med. 2010 Jul;5(4):531-44. doi: 10.2217/rme.10.35.
8
Transcriptome of protoplasts reprogrammed into stem cells in Physcomitrella patens.《拟南芥原生质体重编程为干细胞的转录组》。
PLoS One. 2012;7(4):e35961. doi: 10.1371/journal.pone.0035961. Epub 2012 Apr 24.
9
Reprogramming mediated by stem cell fusion.由干细胞融合介导的重编程。
J Cell Mol Med. 2005 Apr-Jun;9(2):320-30. doi: 10.1111/j.1582-4934.2005.tb00358.x.
10
Enhancing the efficiency of direct reprogramming of human mesenchymal stem cells into mature neuronal-like cells with the combination of small molecule modulators of chromatin modifying enzymes, SMAD signaling and cyclic adenosine monophosphate levels.通过组合染色质修饰酶、SMAD 信号和环磷酸腺苷水平的小分子调节剂来提高人骨髓间充质干细胞向成熟神经元样细胞直接重编程的效率。
Int J Biochem Cell Biol. 2013 Aug;45(8):1633-8. doi: 10.1016/j.biocel.2013.04.022. Epub 2013 May 9.

引用本文的文献

1
Cancer stem cells: landscape, challenges and emerging therapeutic innovations.癌症干细胞：现状、挑战与新兴治疗创新
Signal Transduct Target Ther. 2025 Aug 5;10(1):248. doi: 10.1038/s41392-025-02360-2.
2
Pharmacological modulation of stem cells signaling pathway for therapeutic applications.用于治疗应用的干细胞信号通路的药理学调节。
Stem Cell Res Ther. 2025 Jul 1;16(1):327. doi: 10.1186/s13287-025-04438-8.
3
Revealing the crucial roles of suppressive immune microenvironment in cardiac myxoma progression.揭示抑制性免疫微环境在心脏黏液瘤进展中的关键作用。
Signal Transduct Target Ther. 2024 Aug 2;9(1):193. doi: 10.1038/s41392-024-01912-2.
4
HOX genes in stem cells: Maintaining cellular identity and regulation of differentiation.干细胞中的同源框基因：维持细胞特性与分化调控
Front Cell Dev Biol. 2022 Sep 13;10:1002909. doi: 10.3389/fcell.2022.1002909. eCollection 2022.
5
Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells.卵泡刺激素及其受体在生殖和干细胞及癌症干细胞中的概述。
Int J Biol Sci. 2022 Jan 1;18(2):675-692. doi: 10.7150/ijbs.63721. eCollection 2022.
6
Approaches for Regenerative Healing of Cutaneous Wound with an Emphasis on Strategies Activating the Wnt/β-Catenin Pathway.强调激活 Wnt/β-连环蛋白通路策略的皮肤创面再生修复方法。
Adv Wound Care (New Rochelle). 2022 Feb;11(2):70-86. doi: 10.1089/wound.2020.1284. Epub 2021 Apr 20.
7
Interplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies.上皮-间质转化（EMT）与癌症干细胞（CSC）在癌症中的相互作用及潜在治疗策略
Front Pharmacol. 2020 Jun 17;11:904. doi: 10.3389/fphar.2020.00904. eCollection 2020.
8
Regulation of Hedgehog signaling Offers A Novel Perspective for Bone Homeostasis Disorder Treatment.Hedgehog 信号通路的调控为骨稳态紊乱的治疗提供了新视角。
Int J Mol Sci. 2019 Aug 16;20(16):3981. doi: 10.3390/ijms20163981.
9
Epidermal stem cells in wound healing and their clinical applications.表皮干细胞在创伤愈合中的作用及其临床应用。
Stem Cell Res Ther. 2019 Jul 29;10(1):229. doi: 10.1186/s13287-019-1312-z.
10
Incomplete cellular reprogramming of colorectal cancer cells elicits an epithelial/mesenchymal hybrid phenotype.结直肠癌细胞不完全的细胞重编程会引发上皮/间充质混合表型。
J Biomed Sci. 2018 Jul 19;25(1):57. doi: 10.1186/s12929-018-0461-1.

本文引用的文献

1
Oxidative stress tolerance of early stage diabetic endothelial progenitor cell.早期糖尿病内皮祖细胞的氧化应激耐受性
Regen Ther. 2015 Feb 23;1:38-44. doi: 10.1016/j.reth.2014.11.001. eCollection 2015 Jun.
2
Xenogeneic-free defined conditions for derivation and expansion of human embryonic stem cells with mesenchymal stem cells.用于人胚胎干细胞与间充质干细胞的衍生和扩增的无异种动物成分的限定条件。
Regen Ther. 2015 Feb 19;1:18-29. doi: 10.1016/j.reth.2014.12.004. eCollection 2015 Jun.
3
Flow-dependent regulation of genome-wide mRNA and microRNA expression in endothelial cells in vivo.血流依赖性调节内皮细胞中全基因组 mRNA 和 microRNA 的表达。
Sci Data. 2014 Oct 28;1:140039. doi: 10.1038/sdata.2014.39. eCollection 2014.
4
Regulators of pluripotency and their implications in regenerative medicine.多能性调控因子及其在再生医学中的意义。
Stem Cells Cloning. 2015 Apr 21;8:67-80. doi: 10.2147/SCCAA.S80157. eCollection 2015.
5
An alternative pluripotent state confers interspecies chimaeric competency.一种替代性多能状态赋予种间嵌合能力。
Nature. 2015 May 21;521(7552):316-21. doi: 10.1038/nature14413. Epub 2015 May 6.
6
Origin of cells and network information.细胞起源与网络信息。
World J Stem Cells. 2015 Apr 26;7(3):535-40. doi: 10.4252/wjsc.v7.i3.535.
7
Elimination of tumorigenic human pluripotent stem cells by a recombinant lectin-toxin fusion protein.重组凝集素-毒素融合蛋白消除致瘤性人多能干细胞。
Stem Cell Reports. 2015 May 12;4(5):811-20. doi: 10.1016/j.stemcr.2015.02.016. Epub 2015 Apr 9.
8
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.基于结构的具有增强特性的NANOG变体发现，以促进多能干细胞的自我更新和重编程。
Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4666-71. doi: 10.1073/pnas.1502855112. Epub 2015 Mar 30.
9
Using induced pluripotent stem cells as a tool for modelling carcinogenesis.利用诱导多能干细胞作为致癌建模的工具。
World J Stem Cells. 2015 Mar 26;7(2):461-9. doi: 10.4252/wjsc.v7.i2.461.
10
A continuous molecular roadmap to iPSC reprogramming through progression analysis of single-cell mass cytometry.通过单细胞质谱流式细胞术的进程分析获得诱导多能干细胞重编程的连续分子路线图。
Cell Stem Cell. 2015 Mar 5;16(3):323-37. doi: 10.1016/j.stem.2015.01.015.

干细胞重编程和分化过程中涉及的信号传导。

Signaling involved in stem cell reprogramming and differentiation.

作者信息

Tanabe Shihori

机构信息

Shihori Tanabe, National Institute of Health Sciences, Tokyo 158-8501, Japan.

出版信息

World J Stem Cells. 2015 Aug 26;7(7):992-8. doi: 10.4252/wjsc.v7.i7.992.

DOI:10.4252/wjsc.v7.i7.992
PMID:26328015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4550631/
Abstract

Stem cell differentiation is regulated by multiple signaling events. Recent technical advances have revealed that differentiated cells can be reprogrammed into stem cells. The signals involved in stem cell programming are of major interest in stem cell research. The signaling mechanisms involved in regulating stem cell reprogramming and differentiation are the subject of intense study in the field of life sciences. In this review, the molecular interactions and signaling pathways related to stem cell differentiation are discussed.

摘要

干细胞分化受多种信号事件调控。最近的技术进展表明，分化细胞可被重编程为干细胞。参与干细胞编程的信号是干细胞研究的主要关注点。调控干细胞重编程和分化的信号机制是生命科学领域深入研究的课题。在本综述中，将讨论与干细胞分化相关的分子相互作用和信号通路。