Edwards Jennifer Helen, Reilly Gwendolen Clair
Jennifer Helen Edwards, Gwendolen Clair Reilly, Kroto Research Institute and INSIGNEO Institute for in silico Medicine, Department of Materials Science and Engineering, University of Sheffield, S1 3JD Sheffield, United Kingdom.
World J Stem Cells. 2015 Apr 26;7(3):568-82. doi: 10.4252/wjsc.v7.i3.568.
Due to the increasing burden on healthcare budgets of musculoskeletal system disease and injury, there is a growing need for safe, effective and simple therapies. Conditions such as osteoporosis severely impact on quality of life and result in hundreds of hours of hospital time and resources. There is growing interest in the use of low magnitude, high frequency vibration (LMHFV) to improve bone structure and muscle performance in a variety of different patient groups. The technique has shown promise in a number of different diseases, but is poorly understood in terms of the mechanism of action. Scientific papers concerning both the in vivo and in vitro use of LMHFV are growing fast, but they cover a wide range of study types, outcomes measured and regimens tested. This paper aims to provide an overview of some effects of LMHFV found during in vivo studies. Furthermore we will review research concerning the effects of vibration on the cellular responses, in particular for cells within the musculoskeletal system. This includes both osteogenesis and adipogenesis, as well as the interaction between MSCs and other cell types within bone tissue.
由于肌肉骨骼系统疾病和损伤给医疗保健预算带来的负担日益加重，对安全、有效且简便的治疗方法的需求也在不断增长。诸如骨质疏松症等病症会严重影响生活质量，并导致数百小时的住院时间和资源消耗。人们越来越关注使用低强度、高频振动（LMHFV）来改善各种不同患者群体的骨骼结构和肌肉性能。该技术在多种不同疾病中已显示出前景，但在作用机制方面却知之甚少。关于LMHFV体内和体外应用的科学论文数量迅速增加，但它们涵盖了广泛的研究类型、测量的结果和测试的方案。本文旨在概述体内研究中发现的LMHFV的一些作用。此外，我们将回顾关于振动对细胞反应影响的研究，特别是对肌肉骨骼系统内细胞的影响。这包括骨生成和脂肪生成，以及间充质干细胞与骨组织内其他细胞类型之间的相互作用。
