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接受苯达莫司汀治疗患者的耶氏肺孢子菌预防：制定标准化方案的必要性。

Pneumocystis jiroveci prophylaxis in patients undergoing Bendamustine treatment: the need for a standardized protocol.

作者信息

Abkur Tarig Mohammed, Saeed Mamoun, Ahmed Saad Zeinalabdin, McArthur Ryan, Leahy Maeve, O'Leary Hilary, O'Keeffe Denis

机构信息

Department of Haematology, University Hospital Limerick Limerick, Ireland.

Graduate Entry Medical School, University of Limerick Limerick, Ireland.

出版信息

Clin Case Rep. 2015 Apr;3(4):255-9. doi: 10.1002/ccr3.195. Epub 2015 Feb 9.

DOI:10.1002/ccr3.195
PMID:25914820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4405313/
Abstract

The decision for PJP prophylaxis depends on a physician's evaluation of multiple variables. The high rate of PJP infection described in this article combined with the known impaired T-cell function post Bendamustine treatment justifies considering all patients for PJP prophylaxis when they receive Bendamustine treatment.

摘要

对肺孢子菌肺炎（PJP）进行预防的决策取决于医生对多个变量的评估。本文所述的PJP感染高发生率，再加上已知苯达莫司汀治疗后T细胞功能受损，这使得在所有患者接受苯达莫司汀治疗时考虑进行PJP预防成为合理的做法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d86/4405313/a064cdba66c4/ccr30003-0255-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d86/4405313/166d2c2c9393/ccr30003-0255-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d86/4405313/63965af9501c/ccr30003-0255-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d86/4405313/566d2974ca41/ccr30003-0255-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d86/4405313/1348f789412c/ccr30003-0255-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d86/4405313/a064cdba66c4/ccr30003-0255-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d86/4405313/166d2c2c9393/ccr30003-0255-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d86/4405313/63965af9501c/ccr30003-0255-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d86/4405313/566d2974ca41/ccr30003-0255-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d86/4405313/1348f789412c/ccr30003-0255-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d86/4405313/a064cdba66c4/ccr30003-0255-f5.jpg

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本文引用的文献

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Ann Hematol. 2014 Nov;93(11):1879-87. doi: 10.1007/s00277-014-2135-8. Epub 2014 Jun 21.
2
Bendamustine in indolent non-Hodgkin's lymphoma: a practice guide for patient management.苯达莫司汀治疗惰性非霍奇金淋巴瘤：患者管理实践指南。
Oncologist. 2013;18(8):954-64. doi: 10.1634/theoncologist.2013-0079. Epub 2013 Jul 30.
3
Should Pneumocystis jiroveci prophylaxis be recommended with Rituximab treatment in ANCA-associated vasculitis?
亚洲套细胞淋巴瘤的治疗：亚洲淋巴瘤研究组织的共识文件。
J Hematol Oncol. 2020 Mar 17;13(1):21. doi: 10.1186/s13045-020-00855-9.
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Increased Risk of Infectious Complications in Older Patients With Indolent Non-Hodgkin Lymphoma Exposed to Bendamustine.接受苯达莫司汀治疗的惰性非霍奇金淋巴瘤老年患者感染并发症风险增加。
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