Ather Jennifer L, Poynter Matthew E, Dixon Anne E
Pulmonary and Critical Care Medicine, University of Vermont College of Medicine, Given D208, 89 Beaumont Avenue, Burlington, VT 05405, USA.
Expert Rev Clin Immunol. 2015;11(7):793-803. doi: 10.1586/1744666X.2015.1040394. Epub 2015 Apr 27.
Obesity is associated with severe, poorly controlled asthma that does not respond as well to therapy as asthma in leaner asthmatics. Important insights gained from animal models of obesity and asthma suggests that different forms of obesity may lead to different manifestations of airway disease: obesity is associated with both innate increased airway reactivity and altered responses to aeroallergen and pollutant challenges. In humans, at least two broad groups of obese asthmatics have been recognized: one that is likely unique to obesity and another that is likely lean allergic asthma much complicated by obesity. This article will discuss what we have learned about the immunological and pathophysiological basis of asthma in obesity from animal and human studies, and how this might guide therapy.
肥胖与严重的、控制不佳的哮喘相关，肥胖哮喘患者对治疗的反应不如体型较瘦的哮喘患者。从肥胖和哮喘的动物模型中获得的重要见解表明，不同形式的肥胖可能导致气道疾病的不同表现：肥胖既与先天性气道反应性增加有关，也与对空气过敏原和污染物刺激的反应改变有关。在人类中，至少已识别出两大类肥胖哮喘患者：一类可能是肥胖所特有的，另一类可能是因肥胖而变得更为复杂的瘦型过敏性哮喘。本文将讨论我们从动物和人体研究中了解到的肥胖哮喘的免疫和病理生理基础，以及这如何指导治疗。
