Ma Li-Na, Liu Xiao-Yan, Luo Xia, Hu Yan-Chao, Liu Shuai-Wei, Tang Yuan-Yuan, Pan Jin-Liang, Ding Xiang-Chun
Hepatogastroenterology. 2015 Mar-Apr;62(138):368-72.
BACKGROUND/AIMS: The aim of this study was to explore the potential role of serum high-sensitivity C-reactive protein (hs-CRP) in the pathogenic process of chronic hepatitis B.
A total of 380 patients with chronic hepatitis B were included in this study. All patients received the concentrations of serum hs-CRP, Hepatitis B sero-markers, serum HBV-DNA loads, liver function parameters and liver stiffness were measured, and in which 172 patients undertaken liver biopsy and immunohistochemistry analysis.
Serum hs-CRP concentration in patients with the chronic hepatitis B (2.38 ± 5.52) was significantly higher than healthy controls (0.60 ± 0.53), P < 0.05. The area under ROC curve in fibrosis S4 and S3 is 0.826 and 0.78. The sensitivity and specificity of hs-CRP for fibrosis S3 and S4 diagnosis were 81.8%, 80% and 73.4%, 76.2% respectively (cut off: 1.01 mg/ml, 1.11 mg/l).
C-reactive Protein are associated with HBV replication, liver damage and fibrosis in patients with chronic hepatitis B, and serum High-sensitivity C-reactive Protein may be a marker for diagnosing significant fibrosis in patients with chronic hepatitis B, and can reflect the severity of liver damage.
背景/目的：本研究旨在探讨血清高敏C反应蛋白（hs-CRP）在慢性乙型肝炎致病过程中的潜在作用。
本研究共纳入380例慢性乙型肝炎患者。所有患者均检测血清hs-CRP浓度、乙肝血清学标志物、血清HBV-DNA载量、肝功能参数及肝脏硬度，其中172例患者进行肝活检及免疫组化分析。
慢性乙型肝炎患者血清hs-CRP浓度为（2.38±5.52），显著高于健康对照组（0.60±0.53），P<0.05。纤维化S4和S3的ROC曲线下面积分别为0.826和0.78。hs-CRP对纤维化S3和S4诊断的敏感度和特异度分别为81.8%、80%和73.4%、76.2%（截断值：1.01mg/ml，1.11mg/l）。
C反应蛋白与慢性乙型肝炎患者的HBV复制、肝损伤及纤维化相关，血清高敏C反应蛋白可能是诊断慢性乙型肝炎患者显著纤维化的标志物，并可反映肝损伤的严重程度。
