[胃十二指肠疾病和过敏儿童对幽门螺杆菌的黏膜免疫反应]

[Mucosal immune response to Helicobacter pylori in children with gastroduodenal diseases and allergy].

作者信息

Mazurina S A, Ilintseva N V, Gervazieva V B

出版信息

Eksp Klin Gastroenterol. 2014(9):30-4.

Abstract

In children with chronic gastritis/gastroduodenitis, erosions and ulcer of stomach and duodenum and associated allergic diseases (asthma, allergic rhinitis, atopic dermatitis) CagA, sIgA and IgE antibodies to the H. pylori were determined by ELISA in the supernatants of feces. H. pylori infection was determined according to "Maastricht IV". The frequency and contents of CagA did not differ among the groups we studied. However, in children with positive urease test the contents of CagA was significantly higher (p = 0.03) compared with other children. The highest levels of sIgA were found in the feces supernatants from non-allergic children with CG/CGD and were associated with H. pylori infection. The immune response in children with erosions and ulcer of stomach and duodenum and in children with allergy was presented the sIgE to H. pylori. Also, the negative correlation between the level sIgE to H. pylori and content sIgA was found in children with allergy. Thus, increased IgE indicates not only allergy, but also acts as a protective role in the development of anti-infective immunity.

摘要

在患有慢性胃炎/胃十二指肠炎症的儿童中，通过酶联免疫吸附测定法（ELISA）检测粪便上清液中针对幽门螺杆菌的CagA、分泌型免疫球蛋白A（sIgA）和免疫球蛋白E（IgE）抗体，以观察胃和十二指肠的糜烂及溃疡情况以及相关过敏性疾病（哮喘、过敏性鼻炎、特应性皮炎）。根据“马斯特里赫特IV标准”确定幽门螺杆菌感染情况。我们研究的各小组中，CagA的频率和含量并无差异。然而，脲酶试验呈阳性的儿童中，CagA的含量与其他儿童相比显著更高（p = 0.03）。在患有慢性胃炎/胃十二指肠炎症的非过敏性儿童的粪便上清液中发现了最高水平的sIgA，且其与幽门螺杆菌感染有关。胃和十二指肠有糜烂及溃疡的儿童以及患有过敏症的儿童的免疫反应表现为针对幽门螺杆菌的sIgE。此外，在患有过敏症的儿童中，发现针对幽门螺杆菌的sIgE水平与sIgA含量呈负相关。因此，IgE升高不仅表明过敏，而且在抗感染免疫的发展中起到保护作用。