Senin Lucia L, Al-Massadi Omar, Barja-Fernandez Silvia, Folgueira Cintia, Castelao Cecilia, Tovar Sulay A, Leis Rosaura, Lago Francisca, Baltar Javier, Baamonde Ivan, Dieguez Carlos, Casanueva Felipe F, Seoane Luisa M
Grupo Fisiopatología Endocrina, Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS).; CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Spain; Department of Physiology, Research Centre of Molecular Medicine and Chronic Diseases (CIMUS), Santiago de Compostela, Spain; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Mol Cell Endocrinol. 2015 Aug 15;411:105-12. doi: 10.1016/j.mce.2015.04.016. Epub 2015 Apr 23.
Nesfatin-1, which is derived from the NEFA/nucleobindin 2 (NUCB2) precursor, was recently identified as an anorexigenic peptide that is produced in several tissues including the hypothalamus. Currently, no data exist regarding the regulation of NUCB2/nesfatin-1 production in peripheral tissues, such as gastric mucosa and adipose tissue, through different periods of development. The aim of the present work was to study the variations on circulating levels, mRNA expression and tissue content in gastric mucosa and adipose tissue of NUCB2/nesfatin-1 with age and specially in two clue periods of maturation, weaning and puberty. The weaning period affected NUCB2/nesfatin-1 production in gastric tissue. The testosterone changes associated with the initiation of puberty regulated NUCB2/nesfatin-1 production via adipose tissue and gastric NUCB2/nesfatin-1 production. In conclusion, the production of NUCB2/nesfatin-1 by the stomach and adipose tissue fluctuates with age to regulate energy homeostasis during different states of development.
Nesfatin-1由NEFA/核结合蛋白2（NUCB2）前体衍生而来，最近被确定为一种厌食肽，它在包括下丘脑在内的多个组织中产生。目前，尚无关于在不同发育阶段外周组织（如胃黏膜和脂肪组织）中NUCB2/nesfatin-1产生的调节的数据。本研究的目的是研究随着年龄增长，特别是在两个关键的成熟时期（断奶期和青春期），胃黏膜和脂肪组织中NUCB2/nesfatin-1的循环水平、mRNA表达和组织含量的变化。断奶期影响胃组织中NUCB2/nesfatin-1的产生。与青春期开始相关的睾酮变化通过脂肪组织调节NUCB2/nesfatin-1的产生以及胃中NUCB2/nesfatin-1的产生。总之，胃和脂肪组织中NUCB2/nesfatin-1的产生随年龄波动，以在不同发育状态下调节能量稳态。
