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HIV相关神经认知障碍与抗逆转录病毒治疗：当前概念与争议

HIV-associated Neurocognitive Disorders and Antiretroviral Therapy: Current Concepts and Controversies.

作者信息

Etherton Mark R, Lyons Jennifer L, Ard Kevin L

机构信息

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA,

出版信息

Curr Infect Dis Rep. 2015 Jun;17(6):485. doi: 10.1007/s11908-015-0485-6.

DOI:10.1007/s11908-015-0485-6
PMID:25916996
Abstract

Antiretroviral drugs may help prevent neurological decline in individuals with HIV infection by suppressing viral replication and associated chronic immune activation in the central nervous system. However, HIV control in the brain may come at the price of drug-induced neurotoxicity. Herein, we review recent advances in the balance between adequate viral suppression in the nervous system and adverse effects of the medications used in HIV treatment.

摘要

抗逆转录病毒药物可能通过抑制病毒复制以及中枢神经系统中相关的慢性免疫激活，帮助预防HIV感染者的神经功能衰退。然而，大脑中的HIV控制可能是以药物引起的神经毒性为代价的。在此，我们综述了在神经系统中充分抑制病毒与HIV治疗所用药物的不良反应之间平衡方面的最新进展。

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