Berger Christoph, Bochud Pierre-Yves, Boggian Katja, Cusini Alexia, Egli Adrian, Garzoni Christian, Hirsch Hans H, Hoffmann Matthias, Khanna Nina, Manuel Oriol, Meylan Pascal, Nadal David, van Delden Christian, Weisser Maja, Mueller Nicolas J
Division of Infectious Diseases and Hospital Epidemiology and Children's Research Center, University Children's Hospital of Zürich, Zürich, Switzerland.
Curr Infect Dis Rep. 2015 Jun;17(6):486. doi: 10.1007/s11908-015-0486-5.
Prospective cohort studies significantly contribute to answering specific research questions in a defined population. Since 2008, the Swiss Transplant Cohort Study (STCS) systematically enrolled >95 % of all transplant recipients in Switzerland, collecting predefined data at determined time points. Designed as an open cohort, the STCS has included >3900 patients to date, with a median follow-up of 2.96 years (IQR 1.44-4.73). This review highlights some relevant findings in the field of transplant-associated infections gained by the STCS so far. Three key general aspects have crystallized: (i) Well-run cohort studies are a powerful tool to conduct genetic studies, which are crucially dependent on a meticulously described phenotype. (ii) Long-term real-life observations are adding a distinct layer of information that cannot be obtained during randomized studies. (iii) The systemic collection of data, close interdisciplinary collaboration, and continuous analysis of some key outcome data such as infectious diseases endpoints can improve patient care.
前瞻性队列研究对解答特定人群中的具体研究问题有显著贡献。自2008年以来，瑞士移植队列研究（STCS）系统地纳入了瑞士所有移植受者的95%以上，在特定时间点收集预先定义的数据。STCS设计为开放队列，迄今为止已纳入3900多名患者，中位随访时间为2.96年（四分位间距1.44 - 4.73）。本综述重点介绍了STCS目前在移植相关感染领域获得的一些相关发现。三个关键的总体方面已经明确：（i）运行良好的队列研究是进行基因研究的有力工具，基因研究至关重要地依赖于精心描述的表型。（ii）长期的实际观察正在增加一层独特的信息，这是随机研究中无法获得的。（iii）系统地收集数据、密切的跨学科合作以及对一些关键结局数据（如传染病终点）的持续分析可以改善患者护理。
