Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.
Dermatology. 2021;237(6):970-980. doi: 10.1159/000510685. Epub 2020 Nov 23.
Skin cancer, in particular squamous cell carcinoma, is the most frequent malignancy among solid organ transplant recipients with a higher incidence compared to the general population.
To determine the skin cancer incidence in organ transplant recipients in Switzerland and to assess the impact of immunosuppressants and other risk factors.
Prospective cohort study of solid organ transplant recipients in Switzerland enrolled in the Swiss Transplant Cohort Study from 2008 to 2013.
2,192 solid organ transplant recipients.
Occurrence of first and subsequent squamous cell carcinoma, basal cell carcinoma, melanoma and other skin cancers after transplantation extracted from the Swiss Transplant Cohort Study database and validated by medical record review. Incidence rates were calculated for skin cancer overall and subgroups. The effect of risk factors on the occurrence of first skin cancer and recurrent skin cancer was calculated by the Cox proportional hazard model.
In 2,192 organ transplant recipients, 136 (6.2%) developed 335 cases of skin cancer during a median follow-up of 32.4 months, with squamous cell carcinoma as the most frequent one. 79.4% of skin cancer patients were male. Risk factors for first and recurrent skin cancer were age at transplantation, male sex, skin cancer before transplantation and previous transplantation. For a first skin cancer, the number of immunosuppressive drugs was a risk factor as well.
Skin cancer following solid organ transplantation in Switzerland is greatly increased with risk factors: age at transplantation, male sex, skin cancer before transplantation, previous transplantation and number of immunosuppressive drugs.
皮肤癌，尤其是鳞状细胞癌，是实体器官移植受者中最常见的恶性肿瘤，其发病率高于普通人群。
确定瑞士器官移植受者皮肤癌的发病率，并评估免疫抑制剂和其他危险因素的影响。
对 2008 年至 2013 年期间参加瑞士移植队列研究的瑞士实体器官移植受者进行前瞻性队列研究。
2192 例实体器官移植受者。
从瑞士移植队列研究数据库中提取移植后首次和随后发生的鳞状细胞癌、基底细胞癌、黑色素瘤和其他皮肤癌的发生情况，并通过病历回顾进行验证。计算了皮肤癌总体和亚组的发病率。Cox 比例风险模型计算了危险因素对首次皮肤癌和复发性皮肤癌发生的影响。
在 2192 例器官移植受者中，136 例（6.2%）在中位随访 32.4 个月时发生 335 例皮肤癌，其中鳞状细胞癌最常见。79.4%的皮肤癌患者为男性。首次和复发性皮肤癌的危险因素为移植时年龄、男性、移植前皮肤癌和既往移植。对于首次皮肤癌，免疫抑制药物的数量也是一个危险因素。
瑞士实体器官移植后皮肤癌的发生风险显著增加，危险因素包括：移植时年龄、男性、移植前皮肤癌、既往移植和免疫抑制药物的数量。
