衰老对皮肤微血管系统的影响。
The effect of aging on the cutaneous microvasculature.
作者信息
Bentov Itay, Reed May J
机构信息
Department of Anesthesiology and Pain Medicine, Harborview Medical Center, University of Washington, Seattle, USA.
Division of Gerontology and Geriatric Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, USA.
出版信息
Microvasc Res. 2015 Jul;100:25-31. doi: 10.1016/j.mvr.2015.04.004. Epub 2015 Apr 24.
Aging is associated with a progressive loss of function in all organs. Under normal conditions the physiologic compensation for age-related deficits is sufficient, but during times of stress the limitations of this reserve become evident. Explanations for this reduction in reserve include the changes in the microcirculation that occur during the normal aging process. The microcirculation is defined as the blood flow through arterioles, capillaries and venules, which are the smallest vessels in the vasculature and are embedded within organs and tissues. Optimal strategies to maintain the microvasculature following surgery and other stressors must use multifactorial approaches. Using skin as the model organ, we will review the anatomical and functional changes in the microcirculation with aging, and some of the available clinical strategies to potentially mitigate the effect of these changes on important clinical outcomes.
衰老与所有器官功能的逐渐丧失有关。在正常情况下，对与年龄相关的功能缺陷的生理补偿是足够的，但在压力时期，这种储备的局限性就会变得明显。储备减少的原因包括正常衰老过程中发生的微循环变化。微循环被定义为通过小动脉、毛细血管和小静脉的血流，这些是脉管系统中最小的血管，嵌入器官和组织内。在手术和其他应激源后维持微循环的最佳策略必须采用多因素方法。以皮肤作为模型器官，我们将回顾随着衰老微循环的解剖和功能变化，以及一些可用的临床策略，以潜在地减轻这些变化对重要临床结果的影响。
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