Sriram Rajashree, Gopal V
From the Department of Pharmacognosy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry, India.
Indian J Dermatol. 2025 May-Jun;70(3):135-145. doi: 10.4103/ijd.ijd_210_24. Epub 2025 May 8.
The skin which is a robust predictor of age-related diseases, undergoes morphological and physiological alterations, because of synergistic effects of Intrinsic or Chronological (Age-dependent decline of cell function) and Extrinsic (environmental insults) ageing factors. Ageing is a preordained process that can be determined as the collection of various deleterious changes in cells and tissues. Skin that ages as a consequence of the combination effect of intrinsic and extrinsic factors is characterized by coarseness, wrinkling, hyperpigmentation, telangiectasia, burns and skin sagging. Despite the structural and pathophysiological differences, both types of ageing share several molecular similarities, with the emergence of reactive oxygen species and matrix metalloproteinases induction reflecting as the key aspects of skin ageing. This review elucidates the skin ageing mechanism with a focus on the management of dermatologic ageing that includes treatment strategies and trends in the use of invasive procedures, and energy-based devices which are aimed at addressing skin ageing phenotypes.
皮肤是与年龄相关疾病的有力预测指标，由于内在或自然衰老（细胞功能随年龄下降）和外在衰老（环境损伤）因素的协同作用，会发生形态和生理变化。衰老是一个预先注定的过程，可被定义为细胞和组织中各种有害变化的集合。由于内在和外在因素的综合作用而老化的皮肤，其特征是粗糙、起皱、色素沉着、毛细血管扩张、灼伤和皮肤松弛。尽管两种类型的衰老在结构和病理生理方面存在差异，但它们在分子层面有一些相似之处，活性氧的出现和基质金属蛋白酶的诱导是皮肤衰老的关键方面。本综述阐明了皮肤衰老机制，重点关注皮肤老化的管理，包括治疗策略以及侵入性手术和能量设备的使用趋势，这些都旨在解决皮肤老化的表型问题。
