头颈部鳞状细胞癌治疗后首次 FDG PET/CT 的最佳时机
Optimal timing of first posttreatment FDG PET/CT in head and neck squamous cell carcinoma.
作者信息
Leung Alan S, Rath Tanya J, Hughes Marion A, Kim Seungwon, Branstetter Barton F
机构信息
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Department of Radiology, University of Washington School of Medicine, Seattle, Washington.
出版信息
Head Neck. 2016 Apr;38 Suppl 1:E853-8. doi: 10.1002/hed.24112. Epub 2015 Jul 18.
BACKGROUND
The optimal timing for the initial posttreatment fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT scan after definitive treatment of head and neck squamous cell carcinoma (HNSCC) is unclear.
METHODS
We conducted a retrospective review of 247 patients with definitively treated nonmetastatic HNSCC. First posttreatment PET/CT scans were grouped into: <7 weeks, 7 to 10 weeks, 11 to 14 weeks, and ≥15 weeks. Scans were categorized as positive or negative and accuracy of scans was calculated for each group using biopsy, subsequent imaging, or clinical follow-up for 1 year after treatment as a reference standard.
RESULTS
Sixty-seven of the 247 patients (27.1%) had treatment failure. Scans performed at <7 weeks were less accurate than all other time intervals (p < .05). Scans performed at all other intervals were similar in accuracy.
CONCLUSION
First posttreatment PET/CT can be obtained as early as 2 months after therapy. Scans performed earlier than 2 months have lower accuracy. © 2015 Wiley Periodicals, Inc. Head Neck 38: E853-E858, 2016.
背景
头颈部鳞状细胞癌（HNSCC）根治性治疗后首次治疗后氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）/CT检查的最佳时机尚不清楚。
方法
我们对247例接受根治性治疗的非转移性HNSCC患者进行了回顾性研究。首次治疗后PET/CT扫描分为：<7周、7至10周、11至14周和≥15周。扫描结果分为阳性或阴性，并以活检、后续影像学检查或治疗后1年的临床随访作为参考标准，计算每组扫描的准确性。
结果
247例患者中有67例（27.1%）出现治疗失败。在<7周时进行的扫描准确性低于所有其他时间间隔（p <.05）。在所有其他时间间隔进行的扫描准确性相似。
结论
首次治疗后PET/CT最早可在治疗后2个月进行。早于2个月进行的扫描准确性较低。©2015威利期刊公司。《头颈》38：E853-E858，2016。
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