Northumbria Healthcare NHS Foundation Trust, Department of Medicine, North Tyneside General Hospital, Tyne and Wear, UK Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.
Hai District Hospital, Boman'gombe, Kilimanjaro, Tanzania.
Age Ageing. 2015 Jul;44(4):636-41. doi: 10.1093/ageing/afv048. Epub 2015 Apr 26.
we have previously conducted a community-based prevalence study of dementia in older adults living in the rural Hai district of Tanzania. The aim of this study was to record mortality rates at 4 years post-diagnosis, of those with dementia, mild cognitive impairment (MCI) and no cognitive impairment.
during Phase I of the prevalence study, 1,198 people aged 70 years and over were screened, and a stratified sample of 296 was assessed for the presence of dementia or MCI in Phase II. Seventy-eight people had dementia and 46 had MCI. Four years after diagnosis, we attempted to follow-up all those seen in Phase II and record all deaths.
of the 296, follow-up data were available for 287 (97.0%), including 77 with dementia and 45 with MCI. Of the 172 with no cognitive impairment, 165 (95.9%) were followed up and a sample of 89 people selected as representative of the background population. Forty-eight people with dementia (62.3%), 19 with MCI (42.2%) and 11 with no cognitive impairment (12.4%) had died at 4-year follow-up. After adjusting for the effects of age, gender and education, the hazard ratio was 6.33 (95% CI 3.19-12.58) for dementia and 3.57 (95% CI 1.64-7.79) for MCI relative to people with no cognitive impairment. Mortality rates were highest in those with vascular dementia.
dementia and MCI were associated with excess mortality relative to those with no cognitive impairment.
我们之前在坦桑尼亚农村 Hai 区进行了一项针对老年人群的基于社区的痴呆症患病率研究。本研究的目的是记录诊断后 4 年内痴呆症、轻度认知障碍（MCI）和无认知障碍患者的死亡率。
在患病率研究的第一阶段，对 1198 名 70 岁及以上的老年人进行了筛查，并在第二阶段对 296 名进行了分层抽样，以评估是否存在痴呆症或 MCI。78 人患有痴呆症，46 人患有 MCI。诊断后 4 年，我们试图对所有参加第二阶段的人进行随访，并记录所有死亡情况。
在 296 名参与者中，有 287 名（97.0%）提供了随访数据，其中包括 77 名痴呆症患者和 45 名 MCI 患者。在 172 名无认知障碍的人中，有 165 名（95.9%）进行了随访，并选择了 89 名作为背景人群的代表性样本。在 4 年随访时，48 名痴呆症患者（62.3%）、19 名 MCI 患者（42.2%）和 11 名无认知障碍患者（12.4%）死亡。在调整了年龄、性别和教育程度的影响后，痴呆症的危险比为 6.33（95%CI 3.19-12.58），MCI 为 3.57（95%CI 1.64-7.79），与无认知障碍的人相比。血管性痴呆症患者的死亡率最高。
痴呆症和 MCI 与无认知障碍者相比，死亡率更高。
