Vietnam National Lung Hospital, National Tuberculosis Programme Vietnam, 463 Hoang Hoa Tham street, Badinh District, Hanoi, Vietnam.
Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, Paris, France.
BMC Infect Dis. 2018 Nov 29;18(1):603. doi: 10.1186/s12879-018-3519-5.
Diabetes mellitus (DM) is recognized as an important comorbidity for the development of tuberculosis (TB). With the increase of DM burden globally, concerns have been raised about the emerging co-epidemics of DM and TB, especially in low- and middle-income countries.
A facility-based, cross-sectional study was carried out in all 30 district TB units in Hanoi, Vietnam. All eligible, diagnosed TB patients aged 15 years old or older were asked to provide consent and were screened for diabetes using fasting blood glucose (FBG). Pre-tested semi-structured questionnaires were used for collecting demographic data, lifestyle habits and clinical data. Identification of pre-diabetes or diabetes in TB patients was done in accordance to parameters set by the American Diabetes Association (2016).
Of 870 eligible TB patients, 831 (95.5%) participated in the study. Of those, 241 (29%; 95%CI: 25.9-32.1%) were prediabetic and 114 (13.7%; 95%CI: 11.4-16.1%) were found to have DM. The risk of DM was higher in patients belonging to the age group 40-64 years (OR 6.09; 95%CI 2.81-13.2); or the age group 65 years or older (OR 2.65; 95%CI 1.65-4.25) or who have a family history of DM (OR 2.71; 95%CI 1.33-5.50).
This study demonstrated high prevalence of DM and prediabetes among TB patients in Hanoi, Vietnam. National Tuberculosis Programme needs to establish a systematic screening process for DM among TB patients.
糖尿病（DM）被认为是结核病（TB）发展的重要合并症。随着全球 DM 负担的增加，人们对 DM 和 TB 这两种疾病同时流行的担忧日益加剧，尤其是在中低收入国家。
在越南河内的所有 30 个区结核病单位进行了一项基于机构的横断面研究。所有符合条件的、年龄在 15 岁及以上的已确诊结核病患者都被要求提供同意书，并通过空腹血糖（FBG）筛查糖尿病。使用经过预测试的半结构式问卷收集人口统计学数据、生活方式习惯和临床数据。按照美国糖尿病协会（2016 年）设定的参数确定结核病患者的糖尿病前期或糖尿病状态。
在 870 名符合条件的结核病患者中，有 831 名（95.5%）参与了研究。其中，241 名（29%；95%CI：25.9-32.1%）为糖尿病前期，114 名（13.7%；95%CI：11.4-16.1%）患有糖尿病。年龄在 40-64 岁的患者（OR 6.09；95%CI 2.81-13.2）、年龄在 65 岁或以上的患者（OR 2.65；95%CI 1.65-4.25）或有糖尿病家族史的患者（OR 2.71；95%CI 1.33-5.50）发生糖尿病的风险更高。
本研究表明，越南河内结核病患者中 DM 和糖尿病前期的患病率较高。国家结核病规划需要在结核病患者中建立 DM 的系统筛查程序。
