Steiniche Ditte, Jespersen Sanne, Erikstrup Christian, Krarup Henrik, Handberg Aase, Østergaard Lars, Haraldsdottir Thorny, Medina Candida, Gomes Correira Faustino, Laursen Alex Lund, Bjerregaard-Andersen Morten, Wejse Christian, Hønge Bo Langhoff
Bandim Health Project, Indepth Network, 1004 Bissau, Guinea-Bissau Department of Infectious Diseases, Aarhus University Hospital, 8200 Aarhus N, Denmark
Bandim Health Project, Indepth Network, 1004 Bissau, Guinea-Bissau Department of Infectious Diseases, Aarhus University Hospital, 8200 Aarhus N, Denmark.
Trans R Soc Trop Med Hyg. 2016 Apr;110(4):219-27. doi: 10.1093/trstmh/trw017.
The prevalence of diabetes mellitus (DM) is expected to increase in sub-Saharan Africa. Patients with HIV are at particular risk. We investigated the DM burden among antiretroviral therapy (ART)-naïve patients with HIV in Guinea-Bissau.
Patients were consecutively included. Demographic and lifestyle data were collected and one fasting blood glucose (FBG) measurement was used to diagnose DM (FBG≥7.0 mmol/L) and impaired fasting glucose (IFG) (FBG≥6.1 and <7.0 mmol/L).
By June 2015, 953 newly diagnosed ART-naïve patients with HIV had been included in the study of whom 893 (93.7%) were fasting at the time of inclusion. Median age among the fasting patients was 37 years (IQR 30-46 years) and 562 (62.9%) were women. The prevalence of DM was 5.8% (52/893) while 5.6% (50/893) had IFG. DM was associated with family history of DM (OR 3.92, 95% CI 1.78 to 8.63), being 41-50 years (OR 2.98, 95% CI 1.18 to 7.49) or older than 50 years (OR 3.14, 95% CI 1.09 to 9.07) and Fula ethnicity (OR 2.72, 95% CI 1.12 to 6.62).
DM prevalence was higher among younger patients compared with the background population in Bissau. Traditional risk factors for DM such as advancing age and a family history of DM apply also for ART-naïve patients with HIV.
预计撒哈拉以南非洲地区的糖尿病（DM）患病率将会上升。艾滋病病毒（HIV）感染者面临着特殊风险。我们调查了几内亚比绍未接受抗逆转录病毒治疗（ART）的HIV患者中的糖尿病负担。
连续纳入患者。收集人口统计学和生活方式数据，并使用一次空腹血糖（FBG）测量来诊断糖尿病（FBG≥7.0 mmol/L）和空腹血糖受损（IFG）（FBG≥6.1且<7.0 mmol/L）。
截至2015年6月，953名新诊断的未接受ART的HIV患者被纳入研究，其中893名（93.7%）在纳入时处于空腹状态。空腹患者的中位年龄为37岁（四分位间距30 - 46岁），562名（62.9%）为女性。糖尿病患病率为5.8%（52/893），而IFG患病率为5.6%（50/893）。糖尿病与糖尿病家族史（比值比[OR] 3.92，95%置信区间[CI] 1.78至8.63）、年龄在41 - 50岁（OR 2.98，95% CI 1.18至7.49）或50岁以上（OR 3.14，95% CI 1.09至9.07）以及富拉族（OR 2.72，95% CI 1.12至6.62）相关。
与比绍的背景人群相比，年轻患者中的糖尿病患病率更高。糖尿病的传统风险因素，如年龄增长和糖尿病家族史，在未接受ART的HIV患者中同样适用。
