Huong Phan Thi Thanh, Diep Chau Ngoc, Thanh Nguyen Van, Tu Vu Anh, Hanh Tran Hong, Cuong Nguyen The, Thao Nguyen Phuong, Cuong Nguyen Xuan, Thao Do Thi, Thai Tran Huy, Nam Nguyen Hoai, Ban Ninh Khac, Kiem Phan Van, Minh Chau Van
Nat Prod Commun. 2014 Sep;9(9):1255-7.
Nine secondary metabolites, including a new cycloartane glucoside, rhizostyloside (1), were isolated from a methanol extract of Rhizophora stylosa leaves through several chromatographic experiments. The structures of the compounds were determined on the basis of NMR spectroscopic (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY) and HR-ESI-MS data and by comparison with literature values. Compound 1 exhibited significant cytotoxicity against three human cancer cell lines: KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), and SK-Mel-2 (melanoma). In addition, 1 strongly activated caspase-3/7 in LU-1 cells.
通过多次色谱实验，从红海榄叶的甲醇提取物中分离出9种次生代谢产物，包括一种新的环阿尔廷烷糖苷——根柱草苷（1）。这些化合物的结构是根据核磁共振光谱（1H和13C NMR、HSQC、HMBC、1H-1H COSY、NOESY）和高分辨电喷雾电离质谱数据，并与文献值进行比较确定的。化合物1对三种人类癌细胞系表现出显著的细胞毒性：KB（表皮样癌）、LU-1（肺腺癌）和SK-Mel-2（黑色素瘤）。此外，化合物1在LU-1细胞中强烈激活了caspase-3/7。
