从.中分离得到的一个具有细胞毒性的新卡丹烷倍半萜糖苷。
A new cadinane sesquiterpenoid glucoside with cytotoxicity from .
机构信息
a Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine) , Chinese Academy of Medical Sciences & Peking Union Medical College , Wanning , China.
b Yunnan Branch Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences & Peking Union Medical College , Xishuangbanna , China.
出版信息
Nat Prod Res. 2019 Jun;33(12):1699-1704. doi: 10.1080/14786419.2018.1431635. Epub 2018 Feb 6.
A new cadinane sesquiterpenoid glucoside, 2β,7,3-trihydroxycalamenene 3-O-β-d-glucoside () together with six known compounds, N-(p--coumaroyl)-N-methyl tyramine (), Cleomiscosin A (), 9,12,13-trihydroxy-10,15-heptadecadienoic acid (), Cytochalasin B (), Marmesinin () and N-(p--coumaroyl) tyramine () were obtained from the stem bark of . The new structure of compound was elucidated by analysing its H and C-NMR, H-H COSY, HSQC, HMBC, NOESY and HR-ESI-MS spectra. Compounds showed moderate cytotoxicity against Hela and HepG-2 human cancer cell lines.
一种新的卡丹烷倍半萜糖苷，2β，7，3-三羟基喇叭茶烯 3-O-β-d-葡萄糖苷（），以及六个已知化合物，N-（p-对香豆酰基）-N-甲基酪胺（），Cleomiscosin A（），9,12,13-三羟基-10,15-十七碳二烯酸（），细胞松弛素 B（），Marmesinin（）和 N-（p-对香豆酰基）酪胺（），从 茎皮中分离得到。通过分析其 1H 和 13C-NMR、H-H COSY、HSQC、HMBC、NOESY 和 HR-ESI-MS 谱，确定了化合物的新结构。化合物 对 Hela 和 HepG-2 人癌细胞系表现出中等的细胞毒性。
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