从决明子中分离得到的环阿尔廷三萜及其糖苷。
Cycloartane triterpenoid and its glucoside isolated from Cassia occidentalis.
机构信息
Institute of Molecular Science, Shanxi University, Taiyuan 030006, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
出版信息
Chin J Nat Med. 2017 Dec;15(12):950-954. doi: 10.1016/S1875-5364(18)30012-8.
In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C (1) and its glucoside, cycloccidentaliside VI (2) were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC value of 1.44 μmol·L and TI (Therapeutic Index) value of 15.59.
在本研究中，从 Cassia occidentalis 的全株植物中分离得到了一种新的环阿尔廷三萜类化合物，命名为环西洋酸 C（1）及其糖苷，环西洋昔 VI（2）。通过 1D 和 2D NMR 数据和高分辨质谱的组合分析，确定了它们的结构。化合物 2 表现出适度的抗 HIV-1 活性，EC 值为 1.44 μmol·L，治疗指数（TI）值为 15.59。
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