Sun Yong-Hong, Lei Xiao-Yan, Yuan Hong
Department of Pediatrics, People's Hospital of Gansu Province, First Hospital of Lanzhou University, Lanzhou 730000, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2015 Apr;17(4):371-4.
To compare the clinical and pathological features between children with various genotypes of hepatitis B virus-associated glomerulonephritis (HBV-GN).
Forty-one children with HBV-GN concurrently undergoing liver and renal biopsy were randomly selected. Serum specimens were collected for genotyping and hepatitis B virus (HBV) cccDNA assay. The clinical, pathological, and HBV cccDNA differences between HBV-GN children of various genotypes were analyzed.
Among the 41 HBV-GN children, 29 (71%) were genotype C, 10 (24%) were genotype B, and 2 (5%) were genotype B/C. The incidence rates of hematuria, albuminuria, complement 3 decrease, alanine transaminase increase, and renal insufficiency in the genotype C group were significantly higher than those in the genotype B group (P<0.05). Similarly, the HBV cccDNA positive rate was significantly higher in the genotype C group than that in the genotype B group. No difference was observed in the distribution of pathological types of renal tissues betwee the two geonotype groups. There were no significant differences in the degrees of hepatic inflammation and fibrosis between the two groups.
Mainly genotypes C and B occur in children with HBV-GN and the former genotype is dominant. The clinical symptoms of patients with genotype C are more serious than those with genotype B. However, there is no difference in the pathological features between them.
比较不同基因型乙型肝炎病毒相关性肾小球肾炎（HBV-GN）患儿的临床和病理特征。
随机选取41例同时接受肝脏和肾脏活检的HBV-GN患儿。采集血清标本进行基因分型及乙型肝炎病毒（HBV）cccDNA检测。分析不同基因型HBV-GN患儿的临床、病理及HBV cccDNA差异。
41例HBV-GN患儿中，29例（71%）为C基因型，10例（24%）为B基因型，2例（5%）为B/C基因型。C基因型组患儿血尿、蛋白尿、补体3降低、丙氨酸转氨酶升高及肾功能不全的发生率均显著高于B基因型组（P<0.05）。同样，C基因型组的HBV cccDNA阳性率显著高于B基因型组。两组肾组织病理类型分布无差异。两组肝脏炎症和纤维化程度无显著差异。
HBV-GN患儿主要为C基因型和B基因型，以前者为主。C基因型患儿的临床症状比B基因型患儿更严重。然而，两者的病理特征无差异。
