Kargacin B, Volf V
Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie von Spaltstoffen, Federal Republic Germany.
Hum Toxicol. 1989 Nov;8(6):425-9. doi: 10.1177/096032718900800601.
The estimated intestinal absorption after a single administration of 239Np-nitrate to fasted weanling rats (about 2% of the oral dose) was ten times higher than that of 233Pa administered as the chloride. Rats drinking tomato juice, apple juice or tea instead of water had a similar retention to the control group. However, when a small amount of tea was administered immediately before 239Np, the absorption and retention values were six times lower. When animals received only milk or glucose, the whole body retention of 239Np and 233Pa increased about 20 and 200-300 times, respectively, due mainly to a very high retention in the large intestine. When rats were fed milk plus rat chow, the whole body and gut retention of 233Pa was only two and three times higher, respectively; in the other organs less 233Pa was found than in control animals. This indicates that the extremely high retention of radionuclides in the gut contents of young rats fed only milk is temporary and disappears when solid food is available.
对禁食的断乳幼鼠单次给予硝酸钚-239后，估计的肠道吸收（约为口服剂量的2%）比给予氯化镤-233后的肠道吸收高10倍。饮用番茄汁、苹果汁或茶而非水的大鼠与对照组的潴留情况相似。然而，在给予钚-239之前立即给予少量茶，吸收和潴留值降低了6倍。当动物仅摄入牛奶或葡萄糖时，钚-239和镤-233的全身潴留分别增加了约20倍和200 - 300倍，这主要是由于在大肠中的潴留非常高。当给大鼠喂食牛奶加鼠粮时，镤-233的全身和肠道潴留分别仅高2倍和3倍；在其他器官中发现的镤-233比对照动物中的少。这表明，仅喂食牛奶的幼鼠肠道内容物中放射性核素的极高潴留是暂时的，当有固体食物时就会消失。
