大鼠肝脏中分泌成分的个体发生。
Ontogeny of secretory component in rat liver.
作者信息
Vaerman J P, Buts J P, Lescoat G
机构信息
Catholic University of Louvain, Brussels, Belgium.
出版信息
Immunology. 1989 Nov;68(3):295-9.
The ontogeny of the expression of secretory component (SC), the receptor for transepithelial transport of polymeric immunoglobulins, in the rat liver was assessed by measuring the SC concentration in liver homogenates of rats killed from birth to 60 days of age, and by quantifying the daily SC secretion of in vitro cultured hepatocytes isolated from rats similarly killed from 2 days before birth to 60 days of age. With both methodologies, only very small amounts of SC were produced by the rat liver up to 20 days of age, whereafter expression of SC markedly increased. The development of SC production in the rat liver was co-ordinate with that previously reported in the rat small intestine, preceding the appearance of large numbers of intestinal IgA plasmacytes. These data further emphasize the importance of the liver contribution, via the bile, to the intestinal secretory IgA system of the rat.
通过测量从出生到60日龄处死的大鼠肝脏匀浆中的分泌成分（SC）浓度，以及通过对从出生前2天到60日龄处死的大鼠分离的体外培养肝细胞的每日SC分泌进行定量，评估了大鼠肝脏中聚合免疫球蛋白跨上皮转运受体——分泌成分（SC）表达的个体发生。使用这两种方法，直到20日龄大鼠肝脏仅产生非常少量的SC，此后SC的表达显著增加。大鼠肝脏中SC产生的发育与先前在大鼠小肠中报道的情况一致，先于大量肠道IgA浆细胞的出现。这些数据进一步强调了肝脏通过胆汁对大鼠肠道分泌性IgA系统做出贡献的重要性。
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